| The presence of iodinated contrast agents amplifies DNA radiation damage in computed tomography. | |
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MedLine Citation:
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PMID: 22144029 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The purpose of this study was to determine the influence of iodinated contrast agents on the formation of DNA double-strand breaks in vitro in lymphocytes and to verify these results in patients undergoing diagnostic computed tomography examinations. Blood samples were irradiated in vitro in the presence of iodinated X-ray contrast agent. Controls were irradiated without contrast agent. Fourteen patients were investigated using contrast-enhanced computed tomography (CT), and 14 other patients with unenhanced CT. Blood samples were taken prior to and 5 min and 1, 2 and 24 h after the CT examination. In these blood samples the average number of γH2Ax-foci per lymphocyte was enumerated by fluorescence microscopy. Statistical differences between foci numbers developed in the presence and absence of contrast agent were tested using an independent sample t-test. In vitro foci numbers after irradiation were significantly higher when contrast agent was present during irradiation. In vivo, γH2Ax-foci levels were 58% higher in patients undergoing contrast-enhanced CT compared with those undergoing unenhanced CT. In the presence of iodinated contrast agents DNA, damage is increased and the radiation dose is not the only factor affecting the amount of DNA damage. Individual patient characteristics and biological dosimetry applications, e.g. the analysis of γH2Ax-foci, have to be considered. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Caroline Pathe; Katharina Eble; Daniel Schmitz-Beuting; Boris Keil; Bjoern Kaestner; Maximilian Voelker; Beate Kleb; Klaus J Klose; Johannes T Heverhagen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Contrast media & molecular imaging Volume: 6 ISSN: 1555-4317 ISO Abbreviation: Contrast Media Mol Imaging Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101286760 Medline TA: Contrast Media Mol Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 507-13 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Diagnostic Radiology, Philipps University, Marburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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