Document Detail


The presence of hemoglobin S and C Harlem in an individual in the United States.
MedLine Citation:
PMID:  1148394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first reported case of hemoglobin S and C Harlem in an individual is described. The patient, a 35-yr-old female, had numerous crises during adolescence and early adulthood, but these occurred more infrequently as she grew older. Chemical evidence is presented for the characterization of both variant hemoglobins. The clinical course of this individual with Hb S in combination with Hb C Harlem appears to be similar to that for persons with sickle cell anemia.
Authors:
W Moo-Penn; K Bechtel; D Jue; M S Chan; G Hopkins; N J Schneider; J Wright; R M Schmidt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood     Volume:  46     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / analysis
Anemia, Sickle Cell / blood*
Autoanalysis
Chromatography, DEAE-Cellulose
Cyanogen Bromide
Female
Hemoglobin C* / analysis
Hemoglobin, Sickle* / analysis
Hemoglobins, Abnormal*
Humans
New York City
Peptide Fragments
Trypsin
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Hemoglobin, Sickle; 0/Hemoglobins, Abnormal; 0/Peptide Fragments; 506-68-3/Cyanogen Bromide; 9008-00-8/Hemoglobin C; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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