Document Detail


The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas.
MedLine Citation:
PMID:  11683586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.
Authors:
H Kabashima; M Yoneda; K Nagata; T Hirofuji; Y Ishihara; M Yamashita; K Maeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytokine     Volume:  16     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2002-02-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-6     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Affiliation:
Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chemokine CCL2 / analysis
Chemokine CCL3
Chemokine CCL4
Chemokine CXCL10
Chemokines / analysis*
Chemokines, CXC / analysis
Female
Humans
Immunohistochemistry
Macrophage Inflammatory Proteins / analysis
Male
Middle Aged
Periapical Granuloma / immunology*,  pathology
Receptors, CCR3
Receptors, CCR5 / analysis
Receptors, CXCR3
Receptors, Chemokine / analysis*
Chemical
Reg. No./Substance:
0/CCR3 protein, human; 0/CXCR3 protein, human; 0/Chemokine CCL2; 0/Chemokine CCL3; 0/Chemokine CCL4; 0/Chemokine CXCL10; 0/Chemokines; 0/Chemokines, CXC; 0/Macrophage Inflammatory Proteins; 0/Receptors, CCR3; 0/Receptors, CCR5; 0/Receptors, CXCR3; 0/Receptors, Chemokine

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