| The presence, characterization and prognosis of coronary plaques among patients with zero coronary calcium scores. | |
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MedLine Citation:
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PMID: 20967569 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Patients with coronary artery calcium (CAC) scores of zero are generally considered not to have atherosclerosis. Recent studies involving computed tomography coronary angiography (CTCA) challenge this assumption. This goal of the present study is to assess the frequency, morphology, location, and the prognosis of patients with plaque detected on CTCA and zero CAC. 1,119 patients (51 ± 12 years, 52% male) with a zero CAC score during CTCA study were retrospectively identified. The CTCA studies were assessed for the presence, morphology, location and severity of all coronary plaques. All-cause mortality was assessed. The prevalence of coronary plaque was 13% (147 patients). Among the 212 plaques identified 154 (73%) were non-calcified, 28 (13%) were calcified, and 30 (14%) were of mixed morphology. Notably, ≥70% stenosis was noted among only 0.4% of all patients. ROC analysis revealed that coronary artery disease risk factors did not add to the prediction of plaque among our patients. Over a mean follow-up of 2.5 ± 0.6 years there were 4 deaths (0.4%), all in patients without coronary plaque on CTCA. The presence of coronary plaque is not uncommon among patients with zero CAC scores. These plaques were rarely associated with hemodynamically significant stenoses and were associated with an excellent prognosis. Clinical factors do not appear to be useful in predicting which patients with zero CAC scores have undetected coronary plaque. |
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Authors:
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Seth Uretsky; Alan Rozanski; Padmakshi Singh; Azhar Supariwala; Prashanth Atluri; Sripal Bangalore; Thomas W Pappas; Edward A Fisher; M Robert Peters |
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Publication Detail:
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Type: Journal Article Date: 2010-10-22 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 27 ISSN: 1875-8312 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 805-12 Citation Subset: IM |
Affiliation:
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St. Luke's-Roosevelt Hospital Center, 1111 Amsterdam Avenue, 3rd Floor Cardiology, New York, NY, 10025, USA, suretsky@chpnet.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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