| The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea. | |
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MedLine Citation:
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PMID: 18266209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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JAK2V617F-positive patients with essential thrombocythemia, as opposed to their mutation-negative counterparts, require lower doses of hydroxyurea (HU) for control of their platelet count. In the current study, we looked for predictors of HU response in 69 patients with primary myelofibrosis (PMF) and 56 with polycythemia vera (PV). JAK2V617F analysis was performed on bone marrow-derived DNA obtained at or near the time of diagnosis. HU response in PMF was associated with a shorter disease duration (P = 0.008), absence of previous therapy (P = 0.01), older age at diagnosis (P = 0.009), and presence of JAK2V617F (P = 0.02). On multivariable analysis, only the latter retained its significance (48% vs. 8% response in mutation positive vs. negative cases). In PV, JAK2V617F allele burden correlated directly with HU response (P = 0.05) and inversely with daily HU dose in responding patients (P = 0.02). The current study suggests that JAK2V617F presence identifies PMF patients who are likely to respond to HU therapy, and information on its allele burden helps in assigning the optimal starting dose in individual patients with PV. |
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Authors:
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Shireen Sirhan; Terra L Lasho; Curtis A Hanson; Ruben A Mesa; Animesh Pardanani; Ayalew Tefferi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 83 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-22 Completed Date: 2008-06-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 363-5 Citation Subset: IM |
Copyright Information:
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Copyright 2008 Wiley-Liss, Inc. |
Affiliation:
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Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Alleles Cohort Studies DNA Mutational Analysis Drug Resistance / genetics Female Humans Hydroxyurea / administration & dosage, therapeutic use* Janus Kinase 2 / genetics* Male Middle Aged Mutation, Missense* Platelet Count Point Mutation* Polycythemia Vera / drug therapy, enzymology*, genetics Primary Myelofibrosis / drug therapy, enzymology*, genetics Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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127-07-1/Hydroxyurea; EC 2.7.1.112/JAK2 protein, human; EC 2.7.10.1/Janus Kinase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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