| The presence of HLA-antibodies in recurrent miscarriage patients is associated with a reduced chance of a live birth. | |
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MedLine Citation:
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PMID: 20605049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anti-paternal HLA-antibodies are considered a harmless phenomenon during most pregnancies, whereas their role in recurrent miscarriage (RM) patients is disputed. In contrast to primary RM, patients with secondary RM have carried a fetus to term pregnancy prior to a series of miscarriages, which increases the chance that allogeneic fetal cells appear in the maternal circulation. This study investigates the frequency of HLA-antibodies in secondary RM, primary RM patients and parous controls and analyzes whether the presence of HLA-antibodies in early pregnancy is associated with pregnancy outcome. Sera from women with secondary RM (n=56), primary RM (n=13) and parous controls (n=24) were tested for HLA-antibodies using an ELISA assay and complement dependent cytotoxicity. Samples were taken at gestational week 4-5 in 62 (90%) of the patients. HLA-antibodies were significantly more frequent in secondary RM patients with a boy prior to the miscarriages (62%) compared to secondary RM patients with a firstborn girl (29%, p=0.03), primary RM patients (23%, p=0.02) and parous controls (25%, p=0.005). Forty-one percent of HLA-antibody positive pregnant RM patients had a live birth compared to 76% of HLA-antibody negative RM patients, p=0.006 (adjusted OR: 0.22 (0.07-0.68), p=0.008). In conclusion, HLA-antibodies are significantly more frequent in secondary RM patients with a firstborn boy than in other RM patients and controls. The presence of these antibodies in early pregnancy is associated with a reduced chance of a live birth. Further exploring this association may increase our understanding of maternal acceptance of the fetal allograft. |
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Authors:
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Henriette Svarre Nielsen; Marian D Witvliet; Rudi Steffensen; Geert W Haasnoot; Els Goulmy; Ole Bjarne Christiansen; Frans Claas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 87 ISSN: 1872-7603 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-05-20 Revised Date: 2011-09-16 |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
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Languages: eng Pagination: 67-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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The Fertility Clinic, University Hospital Copenhagen, Rigshospitalet, Fertility Clinic 4071, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. henriette.svarre.nielsen@rh.regionh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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genetics,
immunology* Adult Antibody Specificity Cytotoxicity Tests, Immunologic Enzyme-Linked Immunospot Assay Female HLA Antigens / immunology* Histocompatibility Testing Histocompatibility, Maternal-Fetal* Humans Immune Tolerance Isoantibodies / blood*, immunology Live Birth Odds Ratio Pregnancy / immunology* Pregnancy Outcome Sex Characteristics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/Isoantibodies |
| Comments/Corrections | |
Erratum In:
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J Reprod Immunol. 2011 May;89(2):216 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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