Document Detail


The preparation of phospholipids by phospholipase D.
MedLine Citation:
PMID:  566508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The transfer of the phosphatidyl residue from egg phosphatidylcholine to primary alkanols catalyzed by phospholipase D was systematically investigated. It was demonstrated that 1) the chain length of the alkanols is of critical importance, e.g. transphosphatidylation does not occur to alkanols or alkandiols with more than six carbon atoms; 2) double or triple bonds in the acceptor molecule do not influence the transfer reaction; 3) fluorine is tolerated in the acceptor molecule, but the transfer rate decreases with increasing atomic weight from chlorine to iodine. Synthetic phosphatidylcholines with large variations in the apolar part of the molecule, the phosphorylcholines of 1.2-diacyl-sn-glycerol, Acyl-propandiol-(1.3) and 1.2-cyclopentadecylmethylidene-glycerol, have been successfully used in the transfer reaction. Transesterification is an attractive route for the synthesis of phospholipids differing in the polar part of the molecule.
Authors:
S Kovatchev; H Eibl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  101     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Egg Yolk
Female
Phosphatidylcholines
Phospholipases* / metabolism
Phospholipids / biosynthesis*
Substrate Specificity
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phospholipids; EC 3.1.-/Phospholipases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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