| The preparation of acetic acid for use in otic drops and its effect on endocochlear potential and pH in inner ear fluid. | |
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MedLine Citation:
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PMID: 2596625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ototoxicity of an otic drop preparation containing 2% acetic acid and 3% propylene glycol (VoSol, Denver Chemical Co., Humacao, PR) was investigated according to measurements of endocochlear potential (EP) and inner ear fluid pH. The application of this preparation to the round window membrane for 30 minutes caused a depression in EP from 80.5 +/- 2.5 mV (mean +/- SD; n = 6) to 11.7 +/- 7.7 mV, and lowered inner ear fluid pH from 7.55 +/- 0.09 to 5.06 +/- 0.19 (n = 6) in perilymph and from 7.52 +/- 0.07 to 5.88 +/- 0.63 (n = 6) in endolymph. Two percent acetic acid produced similar changes after 30 minutes: EP was reduced from 83.0 +/- 2.2 mV to 34.0 +/- 2.9 mV and endolymphatic pH from 7.49 +/- 0.04 to 6.83 +/- 0.21 (n = 4). However, the application of artificial perilymph of pH 4 titrated with HCl induced no significant changes in either EP or endolymphatic pH. We suggest that the mechanisms of ototoxicity in the otic drop preparation are Na+ and K+-ATPase inhibition, and that such inhibition is due to the intracellular acidification of strial cells resulting from the penetration of acetic acid across the cell membrane, and to the direct and synergistic actions of propylene glycol. |
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Authors:
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K Ikeda; T Morizono |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of otolaryngology Volume: 10 ISSN: 0196-0709 ISO Abbreviation: Am J Otolaryngol Publication Date: 1989 Nov-Dec |
Date Detail:
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Created Date: 1990-01-22 Completed Date: 1990-01-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 382-5 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Minnesota Medical School, Minneapolis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid Acetic Acids / toxicity* Administration, Topical Animals Chinchilla Cochlear Microphonic Potentials / drug effects* Endolymph / drug effects* Evoked Potentials, Auditory / drug effects* Hydrochloric Acid / toxicity Hydrogen-Ion Concentration Labyrinthine Fluids / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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NINCDS 14538/DS/DS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 64-19-7/Acetic Acid; 7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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