Document Detail


The preoperative treatment of severely anemic patients with a perfluorochemical oxygen-transport fluid, Fluosol-DA.
MedLine Citation:
PMID:  7045667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We gave a perfluorochemical oxygen-transport fluid and plasma expander, Fluosol-DA, to seven severely anemic patients before surgery to determine its effectiveness in supplementing oxygen transport. The dose of Fluosol in the five patients completing the study was 20 ml per kilogram of body weight. When the patients breathed low levels of supplemental oxygen (mean partial pressure of arterial oxygen +/- S.D., 101 +/- 25 torr), the perfluorochemical carried a small amount of oxygen, but when they received pure oxygen (arterial oxygen pressure, 361 +/- 65 torr) it carried approximately 0.8 per cent of oxygen (by volume). This increase accounted for 7 +/- 3 per cent of the patients' arterial oxygen content and 24 +/- 7 per cent of their oxygen consumption. The cardiac index and left ventricular stroke-work index decreased, whereas the oxygen delivery increased, although these changes were not statistically significant. Significant changes included a 22 per cent increase in oxygen consumption, a 59 per cent increase in mixed venous oxygen tension, and an increase in mixed venous hemoglobin saturation to 90 +/- 6 per cent. We conclude that at ambient oxygen tensions fluosol acts primarily as a volume expander, whereas at higher tensions (greater than 300 torr) it contributes substantially to the oxygen-delivery system.
Authors:
K K Tremper; A E Friedman; E M Levine; R Lapin; D Camarillo
Related Documents :
23965067 - Will funding injection avert a winter crisis?
6710547 - Carbon tetrachloride metabolism in vivo and exhalation of volatile alkanes: dependence ...
9288687 - Oxygen transport and utilization during feeding in the young lamb.
18728037 - Effects of phosphorylcholine coating on extracorporeal circulation management and posto...
23409417 - Prevalence of hypertension in a rural community of central india.
15017557 - Quantitation of lung sealing in the survival swine model.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  307     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / blood,  complications*
Arteries
Blood Substitutes / therapeutic use*
Clinical Trials as Topic
Drug Combinations / pharmacology,  therapeutic use
Female
Fluorocarbons / pharmacology,  therapeutic use*
Hemodynamics / drug effects
Hemoglobins / analysis
Humans
Male
Middle Aged
Oxygen / administration & dosage,  blood
Oxygen Consumption / drug effects
Plasma Substitutes / therapeutic use*
Preoperative Care*
Surgical Procedures, Operative*
Veins
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Drug Combinations; 0/Fluorocarbons; 0/Hemoglobins; 0/Plasma Substitutes; 75216-20-5/Fluosol-DA; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The use of an implantable insulin pump in the treatment of type II diabetes.
Next Document:  The relationships of Sivapithecus and Ramapithecus and the evolution of the orang-utan.