Document Detail

The preoperative detection of risk of anaphylaxis during anaesthesia.
MedLine Citation:
PMID:  18084980     Owner:  NLM     Status:  MEDLINE    
In 144 patients who were referred to an anaesthetic allergy clinic because of perceived risk of anaphylaxis during anaesthesia, the only 'at risk' group that could be identified was patients with a history of unexplained severe adverse reaction during previous anaesthesia. Twenty-two of 45 patients with such a history had positive skin tests to an anaesthetic drug. Twenty-one positive tests were to neuromuscular blocking drugs and one to an opiate. In 18 of these patients the medical records were available and an adverse event had been recorded consistent with anaphylaxis. On the contrary, investigation of patients without a previous adverse reaction did not appear to be of value. These findings suggest that those patients with a history of a severe undiagnosed adverse event during previous anaesthesia should be investigated with preoperative skin-testing before undergoing further elective surgery.
M M Fisher
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  35     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  899-902     Citation Subset:  IM    
Department of Anaesthesia, University of Sydney and Intensive Therapy Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
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MeSH Terms
Anaphylaxis / diagnosis,  etiology,  prevention & control*
Anesthetics / adverse effects
Food Hypersensitivity / complications
Preoperative Care / methods*
Referral and Consultation
Risk Factors
Skin Tests
Reg. No./Substance:

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