Document Detail


A preneoplastic stage in the spontaneous neoplastic transformation of syrian hamster embryo cells in culture.
MedLine Citation:
PMID:  7349908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spontaneous neoplastic transformation of Syrian hamster embryo cells in culture occurs in at least two steps. An intermediate stage is represented by an aneuploid cell line which is preneoplastic. These cells differ from the diploid cells by a number of properties, including their ability to become neoplastic in vivo when injected while attached to a substrate. These results support a multistep process for neoplastic transformation of cells in vitro and caution against considering aneuploid cell lines as "normal" cells.
Authors:
J C Barrett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  40     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy*
Animals
Cell Adhesion
Cell Line
Cell Transformation, Neoplastic*
Cricetinae
Embryo, Mammalian
Mesocricetus
Mice
Mice, Nude
Neoplasms, Experimental / genetics
Precancerous Conditions / genetics*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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