Document Detail


The prenatal detection of significant alcohol exposure with maternal blood markers.
MedLine Citation:
PMID:  9738714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the efficacy of a combination of 4 blood markers of alcohol use in detecting alcohol-abusing pregnant women. STUDY DESIGN: Two new markers of alcohol use, whole blood-associated acetaldehyde and carbohydrate-deficient transferrin, and 2 traditional markers of alcohol use, gamma-glutamyl transpeptidase and mean red blood cell volume, were measured in the blood of pregnant women. Each woman was interviewed about alcohol and drug use, medical and obstetric histories, and nutrition. Each infant was examined by a clinician who was blinded to exposure status. RESULTS: All of the women who reported drinking an average of 1 or more ounces of absolute alcohol per day had at least 1 positive blood marker. The infants of mothers with 2 or more positive markers had significantly smaller birth weights, lengths, and head circumferences than the infants with negative maternal screens. The presence of 2 or more positive markers was more predictive of infant outcome than any self-reporting measure. CONCLUSIONS: These markers, which detect more at-risk pregnant women than self-reporting methods, could lead to better efforts at detection and prevention of alcohol-induced fetal damage.
Authors:
J M Stoler; K S Huntington; C M Peterson; K P Peterson; P Daniel; K K Aboagye; E Lieberman; L Ryan; L B Holmes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  133     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-01     Completed Date:  1998-10-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  346-52     Citation Subset:  AIM; IM    
Affiliation:
Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetaldehyde / blood
Adult
Alcohol Drinking / adverse effects*
Biological Markers / blood
Birth Weight
Body Height
Erythrocyte Indices
Ethanol / adverse effects,  poisoning*
Female
Fetal Alcohol Syndrome / diagnosis*,  prevention & control
Head / anatomy & histology
Humans
Infant, Newborn
Medical History Taking
Nutritional Physiological Phenomena
Predictive Value of Tests
Pregnancy / blood*
Pregnancy Outcome
Prenatal Diagnosis*
Prenatal Exposure Delayed Effects*
Reproductive History
Single-Blind Method
Substance-Related Disorders / blood
Transferrin / analysis
gamma-Glutamyltransferase / blood
Grant Support
ID/Acronym/Agency:
5R03AA09049/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 11096-37-0/Transferrin; 64-17-5/Ethanol; 75-07-0/Acetaldehyde; EC 2.3.2.2/gamma-Glutamyltransferase
Comments/Corrections
Comment In:
J Pediatr. 1998 Sep;133(3):316-8   [PMID:  9738707 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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