| The prenatal detection of significant alcohol exposure with maternal blood markers. | |
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MedLine Citation:
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PMID: 9738714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the efficacy of a combination of 4 blood markers of alcohol use in detecting alcohol-abusing pregnant women. STUDY DESIGN: Two new markers of alcohol use, whole blood-associated acetaldehyde and carbohydrate-deficient transferrin, and 2 traditional markers of alcohol use, gamma-glutamyl transpeptidase and mean red blood cell volume, were measured in the blood of pregnant women. Each woman was interviewed about alcohol and drug use, medical and obstetric histories, and nutrition. Each infant was examined by a clinician who was blinded to exposure status. RESULTS: All of the women who reported drinking an average of 1 or more ounces of absolute alcohol per day had at least 1 positive blood marker. The infants of mothers with 2 or more positive markers had significantly smaller birth weights, lengths, and head circumferences than the infants with negative maternal screens. The presence of 2 or more positive markers was more predictive of infant outcome than any self-reporting measure. CONCLUSIONS: These markers, which detect more at-risk pregnant women than self-reporting methods, could lead to better efforts at detection and prevention of alcohol-induced fetal damage. |
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Authors:
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J M Stoler; K S Huntington; C M Peterson; K P Peterson; P Daniel; K K Aboagye; E Lieberman; L Ryan; L B Holmes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 133 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-10-01 Completed Date: 1998-10-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 346-52 Citation Subset: AIM; IM |
Affiliation:
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Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaldehyde
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blood Adult Alcohol Drinking / adverse effects* Biological Markers / blood Birth Weight Body Height Erythrocyte Indices Ethanol / adverse effects, poisoning* Female Fetal Alcohol Syndrome / diagnosis*, prevention & control Head / anatomy & histology Humans Infant, Newborn Medical History Taking Nutritional Physiological Phenomena Predictive Value of Tests Pregnancy / blood* Pregnancy Outcome Prenatal Diagnosis* Prenatal Exposure Delayed Effects* Reproductive History Single-Blind Method Substance-Related Disorders / blood Transferrin / analysis gamma-Glutamyltransferase / blood |
| Grant Support | |
ID/Acronym/Agency:
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5R03AA09049/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 11096-37-0/Transferrin; 64-17-5/Ethanol; 75-07-0/Acetaldehyde; EC 2.3.2.2/gamma-Glutamyltransferase |
| Comments/Corrections | |
Comment In:
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J Pediatr. 1998 Sep;133(3):316-8
[PMID:
9738707
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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