Document Detail


Is prematurity associated with adult cognitive outcome and brain structure?
MedLine Citation:
PMID:  21147382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have indicated that preterm birth and low birth weight are associated with structural brain abnormalities and neurocognitive deficits in childhood and adolescence, although very few studies have included follow-up in adulthood. Here we assessed the effect of preterm delivery (524 subjects; mean 34.6 weeks, S.D. = 1.7) or low birth weight (366 subjects; mean 2159 g, S.D. = 303) on educational and occupational outcomes at age 31 years in the Northern Finland 1966 Birth Cohort, along with 10,132 term, normal birth weight control subjects. Cognitive tests and brain morphology using magnetic resonance imaging were assessed at age 33-35 years in a subset of the cohort (9 subjects; 95 controls). The preterm or low birth weight subjects had slightly lower school ratings and lower educational levels in adulthood, and they performed worse in verbal learning. The low birth weight subjects were less likely to be employed. There were no mean differences in the magnetic resonance imaging tissue segmentation analysis of the brain. In conclusion, although there were no overall changes in brain morphology in the preterm or low birth weight group, there was evidence for slightly poorer educational and occupational careers and cognitive capacity, which may reflect functional disruption not evident in structure.
Authors:
Päivikki Tanskanen; Marita Valkama; Marianne Haapea; Anna Barnes; Khanum Ridler; Jouko Miettunen; Graham K Murray; Juha M Veijola; Peter B Jones; Anja M Taanila; Matti K Isohanni
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurology     Volume:  44     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-04-01     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Achievement
Adolescent
Adult
Brain / pathology*,  physiopathology*
Career Choice
Child
Child, Preschool
Cognition / physiology*
Cohort Studies
Education
Female
Finland / epidemiology
Gestational Age
Humans
Image Processing, Computer-Assisted
Infant
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature / psychology*
Learning / physiology
Longitudinal Studies
Magnetic Resonance Imaging
Male
Memory, Short-Term / physiology
Neuropsychological Tests
Pregnancy
Psychomotor Performance / physiology
Verbal Learning / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
G0701911//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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