| A preliminary study of immunotherapy with a monomethoxy polyethylene glycol modified honey bee venom preparation. | |
MedLine Citation:
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PMID: 3706677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monomethoxy polyethylene glycol (mPEG) modified honey bee venom (HBV) immunotherapy (IT) has been studied in 14 patients allergic to honey bee venom. Doses could be increased more rapidly and higher doses were reached compared to regular venom immunotherapy. No general side effects were seen, although large local swellings were found somewhat more often than with regular HBV. Most patients could easily be switched from the modified to the unmodified venom. Eight patients experienced and tolerated field stings. Skin testing showed a decreased allergenicity of the mPEG-HBV. The mean HBV-specific IgE level was below pre-treatment level already after only 6 weeks of IT. The HBV-specific IgG response was very good. |
Authors:
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S Ohman; J Björkander; S Dreborg; A Lanner; H J Malling; B Weeke |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergy Volume: 41 ISSN: 0105-4538 ISO Abbreviation: Allergy Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-06-06 Completed Date: 1986-06-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7804028 Medline TA: Allergy Country: DENMARK |
Other Details:
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Languages: eng Pagination: 81-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bee Venoms / administration & dosage, immunology, therapeutic use* Female Humans Hypersensitivity* Immunotherapy* Male Middle Aged Polyethylene Glycols / administration & dosage* Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Bee Venoms; 0/Polyethylene Glycols; 9004-74-4/monomethoxypolyethylene glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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