Document Detail


A preliminary study of immunotherapy with a monomethoxy polyethylene glycol modified honey bee venom preparation.
MedLine Citation:
PMID:  3706677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monomethoxy polyethylene glycol (mPEG) modified honey bee venom (HBV) immunotherapy (IT) has been studied in 14 patients allergic to honey bee venom. Doses could be increased more rapidly and higher doses were reached compared to regular venom immunotherapy. No general side effects were seen, although large local swellings were found somewhat more often than with regular HBV. Most patients could easily be switched from the modified to the unmodified venom. Eight patients experienced and tolerated field stings. Skin testing showed a decreased allergenicity of the mPEG-HBV. The mean HBV-specific IgE level was below pre-treatment level already after only 6 weeks of IT. The HBV-specific IgG response was very good.
Authors:
S Ohman; J Björkander; S Dreborg; A Lanner; H J Malling; B Weeke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy     Volume:  41     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-06-06     Completed Date:  1986-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Bee Venoms / administration & dosage,  immunology,  therapeutic use*
Female
Humans
Hypersensitivity*
Immunotherapy*
Male
Middle Aged
Polyethylene Glycols / administration & dosage*
Skin Tests
Chemical
Reg. No./Substance:
0/Bee Venoms; 0/Polyethylene Glycols; 9004-74-4/monomethoxypolyethylene glycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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