Document Detail

A preliminary study on the effect of hormone replacement therapy on peripheral flow velocity in postmenopausal women.
MedLine Citation:
PMID:  9032747     Owner:  NLM     Status:  MEDLINE    
Apart from predisposing to the formation of atherosclerosis in the coronary and cerebrovascular circulation, the menopause is also associated with an increased risk of developing peripheral vascular disease. The aim of this observational study was to determine whether the administration of hormone replacement therapy (HRT) had any effect on peripheral flow velocity in postmenopausal women. Changes in peripheral resistance were recorded in 11 healthy postmenopausal women using Doppler ultrasound. The pulsatility index (PI) of the brachial, radial, dorsalis pedis and popliteal arteries was measured before treatment and every 2 months after the commencement of HRT for 6 months. There was a significant decrease in the PI of the radial and dorsalis pedis arteries after HRT, and there were also reductions in the PI of the brachial and popliteal arteries which were not statistically significant. These changes persisted over the complete study period. Our findings suggest that the administration of HRT will have a beneficial effect on peripheral flow velocity in postmenopausal woman. These changes require confirmation in a larger controlled trial.
T K Lau; T K Chung; C J Haines
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Maturitas     Volume:  26     ISSN:  0378-5122     ISO Abbreviation:  Maturitas     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-07     Completed Date:  1997-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin New Territories, Hong Kong.
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MeSH Terms
Arm / blood supply*
Blood Flow Velocity / drug effects*
Climacteric / drug effects*
Estrogen Replacement Therapy*
Follow-Up Studies
Leg / blood supply*
Middle Aged
Prospective Studies
Ultrasonography, Doppler / drug effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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