Document Detail


A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease.
MedLine Citation:
PMID:  8710089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.
Authors:
G Ramachandran; K Marder; M Tang; P W Schofield; M R Chun; D P Devanand; Y Stern; R Mayeux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  47     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-09-12     Completed Date:  1996-09-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-9     Citation Subset:  AIM; IM    
Affiliation:
Gertrude H. Sergievsky Center, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / psychology*
Apolipoproteins E / genetics*
Female
Genotype*
Humans
Male
Mental Disorders / genetics*
Middle Aged
Psychiatric Status Rating Scales
Grant Support
ID/Acronym/Agency:
AG07232/AG/NIA NIH HHS; AG08702/AG/NIA NIH HHS; AG10963/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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