| A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease. | |
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MedLine Citation:
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PMID: 8710089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations. |
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Authors:
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G Ramachandran; K Marder; M Tang; P W Schofield; M R Chun; D P Devanand; Y Stern; R Mayeux |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 47 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-09-12 Completed Date: 1996-09-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 256-9 Citation Subset: AIM; IM |
Affiliation:
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Gertrude H. Sergievsky Center, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / psychology* Apolipoproteins E / genetics* Female Genotype* Humans Male Mental Disorders / genetics* Middle Aged Psychiatric Status Rating Scales |
| Grant Support | |
ID/Acronym/Agency:
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AG07232/AG/NIA NIH HHS; AG08702/AG/NIA NIH HHS; AG10963/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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