Document Detail


A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium.
MedLine Citation:
PMID:  16925467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the present study was to examine the role of the T-786C endothelial nitric oxide synthase (eNOS) gene polymorphism on changes in renal hemodynamics and blood pressure due to Na(+) loading. Twenty-eight older (63+/-1 years), moderately obese (39+/-2 % fat) hypertensives had their glomerular filtration rate (GFR), renal plasma flow (RPF), blood pressure (BP) and plasma nitric oxide (NO(x)) levels determined after eight days of low (20 mEq) and high (200 mEq) Na(+) diets. The two Na(+) diets were separated by a 1-week washout period. Subjects were genotyped for the eNOS-786 site and were grouped on whether they were homozygous or heterozygous for the C allele (TC+CC, n=13) or only homozygous for the T allele (TT, n=15). The TC+CC genotype group had a significantly greater increase in diastolic (P=0.021) and mean arterial (P=0.018) BP and a significant decline in both RPF (P=0.007) and GFR (P=0.029) compared to the TT genotype group with Na(+) loading. Furthermore, Na(+) loading resulted in a significant (P=0.036) increase in plasma NO(x) in the TT, but not in the TC+CC genotype group as well as a trend (P=0.051) for an increase in urine NO(x) in TC+CC, but not in the TT genotype group. The increase in BP during Na(+) loading in older hypertensives was associated with the eNOS genotype and may be related to changes in renal hemodynamics due to changes in NO metabolism.
Authors:
D R Dengel; M D Brown; R E Ferrell; T H Reynolds; M A Supiano
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-08-22
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  56     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-11-20     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  393-401     Citation Subset:  IM    
Affiliation:
University of Minnesota, Minneapolis, USA. denge001@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects*
Diet, Sodium-Restricted*
Double-Blind Method
Female
Genetic Predisposition to Disease
Glomerular Filtration Rate / drug effects
Heterozygote
Homozygote
Humans
Hypertension / enzymology,  genetics*,  metabolism,  physiopathology
Male
Middle Aged
Nitric Oxide / blood
Nitric Oxide Synthase Type III / genetics*,  metabolism
Phenotype
Pilot Projects
Polymorphism, Genetic*
Renal Circulation / drug effects*
Severity of Illness Index
Sodium / blood,  urine
Sodium Chloride, Dietary / administration & dosage*
Time Factors
Treatment Outcome
Grant Support
ID/Acronym/Agency:
K24 AG 000924/AG/NIA NIH HHS; KO1 AG0072301/AG/NIA NIH HHS; RR-00042/RR/NCRR NIH HHS; U10HL54526/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Sodium Chloride, Dietary; 10102-43-9/Nitric Oxide; 7440-23-5/Sodium; EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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