Document Detail


A preliminary result of treatment of neuromyelitis optica with autologous peripheral hematopoietic stem cell transplantation.
MedLine Citation:
PMID:  21150387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline. The MRI abnormalities on T1WI and T2WI improved. The postpartum maternal blood helper T (CD3+CD4+ T cell) and the CD4+/CD8+ ratio were decreased, and the cytotoxic T (CD3+CD8+ T) cell increased. This shows that APHSCT in this patient with neuromyelitis optica appears to reduce the frequency of attacks with improvement in disability. However, a larger study with more patients and a longer follow-up would be required to assess the encouraging preliminary results.
Authors:
Fuhua Peng; Wei Qiu; Jin Li; Xueqiang Hu; Renwei Huang; Dongjun Lin; Jian Bao; Ying Jiang; Lianfang Bian
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The neurologist     Volume:  16     ISSN:  2331-2637     ISO Abbreviation:  Neurologist     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-14     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  9503763     Medline TA:  Neurologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation / methods*
Humans
Magnetic Resonance Imaging
Neuromyelitis Optica / surgery*
Transplantation, Autologous*
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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