Document Detail

A preliminary result of treatment of neuromyelitis optica with autologous peripheral hematopoietic stem cell transplantation.
MedLine Citation:
PMID:  21150387     Owner:  NLM     Status:  MEDLINE    
Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline. The MRI abnormalities on T1WI and T2WI improved. The postpartum maternal blood helper T (CD3+CD4+ T cell) and the CD4+/CD8+ ratio were decreased, and the cytotoxic T (CD3+CD8+ T) cell increased. This shows that APHSCT in this patient with neuromyelitis optica appears to reduce the frequency of attacks with improvement in disability. However, a larger study with more patients and a longer follow-up would be required to assess the encouraging preliminary results.
Fuhua Peng; Wei Qiu; Jin Li; Xueqiang Hu; Renwei Huang; Dongjun Lin; Jian Bao; Ying Jiang; Lianfang Bian
Related Documents :
2074607 - Direct modification of obsessive thinking with messages.
21387457 - β-globin gene cluster haplotypes in sickle cell patients from panamá.
1797717 - Technical approaches to transference hate in the analysis of borderline patients.
3297777 - Structure, self-regulating sequences, and institutional third parties in therapy: the v...
24713797 - Role of endoscopic ultrasonography (eus) in management of benign esophageal strictures.
7332647 - A neutrophil lysozyme leak in patients with familial mediterranean fever.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The neurologist     Volume:  16     ISSN:  2331-2637     ISO Abbreviation:  Neurologist     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-14     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  9503763     Medline TA:  Neurologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation / methods*
Magnetic Resonance Imaging
Neuromyelitis Optica / surgery*
Transplantation, Autologous*
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neurologic soft signs in Behcet disease.
Next Document:  Calcified brainstem cavernoma in a patient with hundreds of intracranial cavernomas.