| A preliminary result of treatment of neuromyelitis optica with autologous peripheral hematopoietic stem cell transplantation. | |
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MedLine Citation:
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PMID: 21150387 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline. The MRI abnormalities on T1WI and T2WI improved. The postpartum maternal blood helper T (CD3CD4 T cell) and the CD4/CD8 ratio were decreased, and the cytotoxic T (CD3CD8 T) cell increased. This shows that APHSCT in this patient with neuromyelitis optica appears to reduce the frequency of attacks with improvement in disability. However, a larger study with more patients and a longer follow-up would be required to assess the encouraging preliminary results. |
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Authors:
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Fuhua Peng; Wei Qiu; Jin Li; Xueqiang Hu; Renwei Huang; Dongjun Lin; Jian Bao; Ying Jiang; Lianfang Bian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The neurologist Volume: 16 ISSN: 1074-7931 ISO Abbreviation: Neurologist Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503763 Medline TA: Neurologist Country: United States |
Other Details:
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Languages: eng Pagination: 375-8 Citation Subset: IM |
Affiliation:
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Departments of *Neurology † Hematology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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