| A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks. | |
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MedLine Citation:
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PMID: 21812784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition. METHODS: We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks. RESULTS: The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period. CONCLUSIONS: Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome. |
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Authors:
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James N Mubiru; Magdalena Garcia-Forey; Paul B Higgins; Peggah Hemmat; Nicole E Cavazos; Edward J Dick; Michael A Owston; Cassondra A Bauer; Robert E Shade; Anthony G Comuzzie; Jeffrey Rogers |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-08-03 |
Journal Detail:
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Title: Journal of medical primatology Volume: 40 ISSN: 1600-0684 ISO Abbreviation: J. Med. Primatol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: 2012-02-02 Revised Date: 2012-02-20 |
Medline Journal Info:
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Nlm Unique ID: 0320626 Medline TA: J Med Primatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 335-41 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA. jmubiru@TxBiomed.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon
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veterinary Animals Biological Markers / blood* Blood Glucose / analysis Body Composition* Body Weight* Cholesterol / blood, chemistry Dietary Carbohydrates / administration & dosage*, adverse effects Dietary Fats / administration & dosage*, adverse effects Energy Metabolism Insulin / blood Macaca fascicularis / metabolism* Male Metabolic Syndrome X / blood, etiology, physiopathology, veterinary* Models, Animal Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR013556/RR/NCRR NIH HHS; K01RR025161-01/RR/NCRR NIH HHS; P51 RR0139986/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Insulin; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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