Document Detail


A preliminary report on the effect of dietary energy on prostaglandin F2 alpha production in vitro, interferon-tau synthesis by the conceptus, endometrial progesterone concentration on days 9 and 15 of pregnancy and associated rates of embryo wastage in ewes.
MedLine Citation:
PMID:  10735098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two groups of ewes were fed to provide 1.70 x (high energy group; n = 15) or 0.56 x (low energy group; n = 15) energy requirements for maintenance of liveweight from 14 d before a synchronized mating in November until slaughter at 9 or 15 d after mating. We investigated the effects on interferon-tau (IFN tau) secretion by the conceptuses, prostaglandin F2 alpha (PG) production in vitro by endometrial tissue, and associated rates of embryo mortality, endometrial progesterone content and progesterone production by luteal tissue. No differences between groups in pregnancy rate were detected on Day 9 between the 2 groups. Proportionately (6/6 vs 2/5), there were more pregnant ewes in the high energy group on Day 15, although this difference did not reach significance (P = 0.06). The proportion of corpora lutea represented by embryos was significantly lower in undernourished ewes (P < 0.05). Secretion in vitro of PG was lower in the 2 pregnant ewes of the low energy group on Day 15, and it was accompanied by higher IFN tau secretion by conceptuses recovered from these ewes. However, the limited number of pregnant ewes recorded on Day 15 prevented any statistical comparison. Neither mean endometrial content of progesterone nor ovarian venous progesterone concentrations and production of progesterone by luteal were affected by nutrition. The provisional results of the present experiment indicate that undernutrition may induce a reduction in the rate of secretion of IFN tau and can therefore increase production of PG from the endometrium. This could initiate luteolysis. The lower pregnancy rates observed in underfed ewes could be mediated through this alteration in the signal of maternal recognition of pregnancy. However, these findings remain to be shown in further experiments including a larger number of animals, as they only represent data from 2 undernourished animals.
Authors:
J A Abecia; F Forcada; J M Lozano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Theriogenology     Volume:  52     ISSN:  0093-691X     ISO Abbreviation:  Theriogenology     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-04-19     Completed Date:  2000-04-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1203-13     Citation Subset:  IM    
Affiliation:
Departamento de Producción Animal y Ciencia de los Alimentos, Universidad de Zaragoza, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animal Nutritional Physiological Phenomena*
Animals
Corpus Luteum / physiology
Dinoprost / biosynthesis*
Embryonic and Fetal Development
Endometrium / physiology*
Energy Metabolism
Female
Fetal Death / epidemiology,  veterinary
Gestational Age
Interferon Type I / biosynthesis*
Ovulation
Pregnancy
Pregnancy Proteins / biosynthesis*
Pregnancy, Animal / physiology*
Progesterone / blood,  metabolism*
Sheep
Sheep Diseases / embryology,  epidemiology
Chemical
Reg. No./Substance:
0/Interferon Type I; 0/Pregnancy Proteins; 0/trophoblastin; 551-11-1/Dinoprost; 57-83-0/Progesterone

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