Document Detail

A preliminary observation of weight loss following left gastric artery embolization in humans.
MedLine Citation:
PMID:  25349724     Owner:  NLM     Status:  In-Data-Review    
Background/Objectives. Embolization of the left gastric artery (LGA), which preferentially supplies the gastric fundus, has been shown to produce weight loss in animal models. However, weight loss after LGA embolization in humans has not been previously established. The aim of this study was to evaluate postprocedural weight loss in patients following LGA embolization. Subjects/Methods. A retrospective analysis of the medical records of patients who underwent LGA embolization for upper gastrointestinal (GI) bleeding was performed. Postprocedural weight loss in this group was compared to a control group of patients who had undergone embolization of other arteries for upper GI bleeding. Results. The experimental group (N = 19) lost an average of 7.3% of their initial body weight within three months of LGA embolization, which was significantly greater than the 2% weight loss observed in the control group (N = 28) (P = 0.006). No significant differences were seen between the groups in preprocedural body mass index (BMI), age, postprocedural care in the intensive care unit, history of malignancy, serum creatinine, or left ventricular ejection fraction. Conclusions. The current data suggest that body weight in humans may be modulated via LGA embolization. Continued research is warranted with prospective studies to further investigate this phenomenon.
Andrew J Gunn; Rahmi Oklu
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Publication Detail:
Type:  Journal Article     Date:  2014-09-30
Journal Detail:
Title:  Journal of obesity     Volume:  2014     ISSN:  2090-0716     ISO Abbreviation:  J Obes     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526295     Medline TA:  J Obes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185349     Citation Subset:  IM    
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