Document Detail

A preliminary morphometric study on the endometrium from patients treated with indomethacin-releasing copper intrauterine device.
MedLine Citation:
PMID:  9262297     Owner:  NLM     Status:  MEDLINE    
The intrauterine device (IUD) is an effective method of birth control. However, IUD-induced uterine bleeding is a major side-effect and always causes inconvenience, sometimes even anaemia. It has been reported that oral administration of indomethacin could can reduce IUD-induced uterine bleeding. In the present study, we investigated whether indomethacin-releasing copper IUD (IR-Cu-IUD) can prevent insertion-induced uterine bleeding and its mechanism. Nine healthy volunteers of reproductive age were selected for the study. Endometrial tissues were collected at same menstrual stage prior to and 3-6 months after IR-Cu-IUD insertion. Endometrial morphology, cell proliferation/differentiation, morphometry and activity of complement Factor VIII were examined. No significant difference was found in any of the parameters examined in the same patients, both prior to and after IR-Cu-IUD insertion. By comparison with data previously obtained from the patients who had Cu-IUD insertions, it is clear that IR-Cu-IUD markedly reduced IUD-induced uterine bleeding and this reduction is primarily contributed by the anti-inflammatory action of indomethacin.
G Zhao; M Li; P Zhu; R Xu; J Wang; R Xu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  12     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-26     Completed Date:  1997-09-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1563-6     Citation Subset:  IM    
Pyong Yang Maternity Hospital, DPRK, Beijing, China.
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MeSH Terms
Cell Differentiation
Cell Division
Endometrium / chemistry,  cytology*
Factor VIII / analysis
Indomethacin / administration & dosage*,  adverse effects,  therapeutic use
Intrauterine Devices, Copper / adverse effects*
Uterine Hemorrhage / etiology*,  prevention & control*
Reg. No./Substance:
53-86-1/Indomethacin; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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