Document Detail


The preliminary experimental and clinical study of the relationship between the pigment gallstone and intestinal mucosal barrier.
MedLine Citation:
PMID:  19486450     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To investigate the relations between the formation of pigment gallstone and the function of the intestinal mucosal barrier, as well as the underlying mechanism. METHODS: Eighty guinea pigs were randomly divided into three groups in which they were respectively given normal diet, gallstone-causing diet, and gallstone-formation diet with a supplementary intestinal mucosal protection compound known as glutamine. The model of pigment gallstone was established after 8 weeks of dietary administration. Indices about the function of the intestinal mucosal barrier and bacterial translocation were measured. Clinical cases were divided into three groups: control, cholesterol gallstone, and pigment gallstone, where the levels of plasma diamine oxidase (DAO), plasma endotoxin and the excretion rates of technetium 99m-diethylene triamine pentaacetic acid (99mTC-DTPA) in the urine of each group were measured. RESULTS: In the pigment gallstone group, the level of plasma DAO and endotoxin, the excretory ratio of lactulose and mannitol in urine, the bacterial translocation ratio in the celiac lymph nodes and the activities of beta-glucuronidase increased comparing to the control group. The gallstone-formation rate for the intestinal mucosal protection group (GLN) decreased, and other indices, except the activity of beta-glucuronidase, were all lower than that of gallstone-formation group. In the clinical experiment, the levels of plasma DAO and endotoxin, as well as the excretory rate of 99mTC-DTPA in urine were higher in the patients with gallstones than that in the control group. CONCLUSIONS: The formation of pigment gallstone was related to the abnormal function of the intestinal mucosal barrier. The abnormality in the function of the intestinal mucosal barrier probably induced the formation of gallstone by a bacterial translocation mechanism.
Authors:
Yang Su; Shuodong Wu; Ying Fan; Junzhe Jin; Zhenhai Zhang
Publication Detail:
Type:  Journal Article     Date:  2009-04-13
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  24     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1451-6     Citation Subset:  IM    
Affiliation:
Department of First Micro-injury and Biliary Surgery, Shenjing Hospital of China Medical University, Shenyang, China.
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MeSH Terms
Descriptor/Qualifier:
Amine Oxidase (Copper-Containing) / blood
Animals
Bacterial Translocation* / drug effects
Bile / enzymology
Bile Pigments / metabolism*
Case-Control Studies
Cholesterol / metabolism
Disease Models, Animal
Endotoxins / blood
Female
Gallstones / drug therapy,  metabolism*,  microbiology
Glucuronidase / metabolism
Glutamine / pharmacology
Guinea Pigs
Humans
Intestinal Mucosa / drug effects,  metabolism*,  microbiology
Lactulose / urine
Lymph Nodes / microbiology
Male
Mannitol / urine
Permeability
Pilot Projects
Radiopharmaceuticals / diagnostic use,  urine
Technetium Tc 99m Pentetate / diagnostic use,  urine
Chemical
Reg. No./Substance:
0/Bile Pigments; 0/Endotoxins; 0/Radiopharmaceuticals; 4618-18-2/Lactulose; 56-85-9/Glutamine; 57-88-5/Cholesterol; 65454-61-7/Technetium Tc 99m Pentetate; 69-65-8/Mannitol; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 3.2.1.31/Glucuronidase

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