| Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection. | |
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MedLine Citation:
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PMID: 23100477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging. |
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Authors:
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Ennio Polilli; Giustino Parruti; Francesca D'Arcangelo; Elisa Tracanna; Luigi Clerico; Vincenzo Savini; Francesco D'Antonio; Maurizio Rosati; Lamberto Manzoli; Domenico D'Antonio; Giovanni Nigro |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-10-24 |
Journal Detail:
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Title: Clinical and vaccine immunology : CVI Volume: 19 ISSN: 1556-679X ISO Abbreviation: Clin. Vaccine Immunol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-28 Completed Date: 2013-04-29 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 101252125 Medline TA: Clin Vaccine Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1991-3 Citation Subset: IM |
Affiliation:
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Microbiology and Virology Unit, General Hospital of Pescara, Pescara, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytomegalovirus Infections / therapy* Female Humans Immunoglobulins, Intravenous / therapeutic use* Immunotherapy / methods* Infusions, Intravenous Pregnancy Pregnancy Complications, Infectious / therapy* Pregnant Women |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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