Document Detail


Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.
MedLine Citation:
PMID:  23100477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.
Authors:
Ennio Polilli; Giustino Parruti; Francesca D'Arcangelo; Elisa Tracanna; Luigi Clerico; Vincenzo Savini; Francesco D'Antonio; Maurizio Rosati; Lamberto Manzoli; Domenico D'Antonio; Giovanni Nigro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-24
Journal Detail:
Title:  Clinical and vaccine immunology : CVI     Volume:  19     ISSN:  1556-679X     ISO Abbreviation:  Clin. Vaccine Immunol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-28     Completed Date:  2013-04-29     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101252125     Medline TA:  Clin Vaccine Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1991-3     Citation Subset:  IM    
Affiliation:
Microbiology and Virology Unit, General Hospital of Pescara, Pescara, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cytomegalovirus Infections / therapy*
Female
Humans
Immunoglobulins, Intravenous / therapeutic use*
Immunotherapy / methods*
Infusions, Intravenous
Pregnancy
Pregnancy Complications, Infectious / therapy*
Pregnant Women
Chemical
Reg. No./Substance:
0/Immunoglobulins, Intravenous
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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