Document Detail


Is prehypertension really different from normotension and hypertension? A case-control pilot proteomic study in Chinese.
MedLine Citation:
PMID:  19811360     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to investigate the differences in the plasma proteome of healthy normotensive, prehypertensive, and hypertensive subjects. A case-control pilot study was conducted among well-matched subjects. Plasma protein was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry. The results showed that there were 22 differentially expressed spots among the three groups, which corresponded to 18 proteins involved in inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and anti-oxidation. With an increase in blood pressure, these proteins were differentially expressed which indicated that prehypertension probably was an early stage of hypertension.
Authors:
Zuoguang Wang; Xiaoyun Peng; Yanduo Tao; Ya Liu; Jieling Liu; Xingjun Chen; Shaojun Wen; Zhaosu Wu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  31     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-10-08     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  316-29     Citation Subset:  IM    
Affiliation:
Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, PR, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis / physiology
Blood Pressure / physiology*
Case-Control Studies
Cell Proliferation
China
Diagnosis, Differential
Electrophoresis, Gel, Two-Dimensional
Fibrinolysis / physiology
Humans
Hypertension / blood*,  diagnosis*,  ethnology
Immunity / physiology
Inflammation / metabolism
Lipid Metabolism / physiology
Male
Middle Aged
Pilot Projects
Proteome / metabolism*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical
Reg. No./Substance:
0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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