Document Detail


Is pregnancy a model how we should control some autoimmune diseases?
MedLine Citation:
PMID:  12515284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy and parturition are the physiological conditions that affect the course and severity of numerous autoimmune diseases. If genotype might be primarily considered as a determinant of whether or not autoimmunity develops, clinical heterogeneity of the disease might arise from the interaction of the genotype and the environment. Numerous external factors with extremely important immunoregulatory properties, including hormones, affect an in vivo open complex immune system. The further investigation of the role of neuroendocrine-immunological network, including a pregnancy-associated immunomodulation, as much as the role of "causative" or "trigger" agents, may allow the rational basis of new alternative treatment of numerous autoimmune diseases.
Authors:
Sanja Draca
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Autoimmunity     Volume:  35     ISSN:  0891-6934     ISO Abbreviation:  Autoimmunity     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2003-01-07     Completed Date:  2003-05-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
Affiliation:
Clinic Dr M. Zotović, Sokobanjska 13, 11 000 Belgrade, Yugoslavia. odracha@eunet.yu
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / complications,  immunology,  therapy
Autoimmune Diseases / complications,  etiology,  therapy*
Autoimmunity
Female
Humans
Lupus Erythematosus, Systemic / complications,  immunology,  therapy
Models, Immunological*
Neuroimmunomodulation
Pregnancy / immunology*
Pregnancy Complications / immunology
Th1 Cells / immunology
Th2 Cells / immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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