Document Detail


The preferential location of the human Y chromosome in somatic metaphase. I. Influence of Y polymorphism.
MedLine Citation:
PMID:  3700125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The location of the Y chromosome in metaphase figures was studied, with respect to its polymorphism, on 700 micrographs from blood lymphocyte cultures from 70 normal male members of seven Canadian family lines whose polymorphic Y chromosomes were inherited in a patrilinear fashion from seventeenth-century French ancestors. Three of these family lines were carriers of a long Y chromosome, two a small one, one had an average length Y and a seventh one had a satellited Y marker. The Y chromosome was peripheral in 75 to 90 per cent of the metaphase plates from each individual investigated. The long Y markers were more peripheral than the small ones while the average length Y chromosome had an intermediate position, whereas the satellited Y chromosome was located within the small group. The difference between the location of the long and the small Y chromosomes was highly significant. It is hypothesised that a heteromorphic Y might affect the nonrandom orientation of metaphasic chromosomes and favour meiotic nondisjunction and aneuploidy.
Authors:
P Genest; F B Genest; D Genest
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heredity     Volume:  56 ( Pt 2)     ISSN:  0018-067X     ISO Abbreviation:  Heredity     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-11     Completed Date:  1986-06-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  203-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Chromosome Banding
Humans
Karyotyping
Lymphocytes / cytology
Male
Metaphase
Polymorphism, Genetic*
Y Chromosome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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