Document Detail


The preeminence of growth pattern and invasiveness and the limited influence of BRAF and RAS mutations in the occurrence of papillary thyroid carcinoma lymph node metastases.
MedLine Citation:
PMID:  21796448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prognostic factors indicative of papillary thyroid carcinoma (PTC) aggressive behaviour remain incompletely established partially due to the different composition of the series on record regarding the relative proportion of classic PTC (CPTC) and follicular variant PTC (FVPTC) subtypes. Several clinico-morphological features of PTC, together with the occurrence of BRAF mutations, are still not fully accepted as markers of aggressiveness. In the present clinico-pathological study of a series of 75 CPTC and FVPTC cases, we evaluated the relative contribution of the morphological features of the tumours and their BRAF and N-RAS status for the occurrence of nodal metastases. The morphological features most closely related to the occurrence of nodal metastases were extra-thyroid extension and poorly circumscribed growth pattern, in both CPTC and FVPTC. Additional features significantly associated to nodal metastases were multicentricity in the CPTC and vascular invasion in the FVPTC group. BRAF V600E mutation was detected in 29% of tumours, 41% of CPTC and 16% of FVPTC; N-RAS Q61R mutation was detected in 6% of tumours, 3% of CPTC and 10% of FVPTC. BRAF mutation was significantly more frequent in the CPTC group and in females, and it was detected only in patients older than 20 years, suggesting a late tumourigenic effect in the development of PTC. BRAF mutation was not significantly associated to any of the other studied features related to aggressiveness or nodal metastases. These results highlight the importance of infiltrative growth pattern and invasiveness over the presence of BRAF mutation in classic and follicular variant PTC for the development of nodal metastases.
Authors:
Catarina Eloy; Joana Santos; Paula Soares; Manuel Sobrinho-Simões
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-28
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  459     ISSN:  1432-2307     ISO Abbreviation:  Virchows Arch.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2011-11-09     Revised Date:  2012-06-21    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  265-76     Citation Subset:  IM    
Affiliation:
Pathology Department, Hospital de São João, Oporto, Portugal. catarinaeloy@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma, Papillary, Follicular / genetics,  pathology
Female
Genes, ras*
Humans
Lymphatic Metastasis / genetics*
Male
Middle Aged
Mutation*
Neoplasm Invasiveness
Proto-Oncogene Proteins B-raf / genetics*
Thyroid Neoplasms / genetics*,  pathology*
Chemical
Reg. No./Substance:
EC 2.7.11.1/BRAF protein, human; EC 2.7.11.1/Proto-Oncogene Proteins B-raf

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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