Document Detail


The predictive values of beta1-adrenergic and M2 muscarinic receptor autoantibodies for sudden cardiac death in patients with chronic heart failure.
MedLine Citation:
PMID:  22713286     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: Clinical and animal studies suggest that beta(1)-adrenergic and M(2) muscarinic receptor autoantibodies (beta(1)-AAbs and M(2)-AAbs) play important roles in the pathophysiological process of chronic heart failure (CHF). Removal of these autoantibodies improved haemodynamic parameters and left ventricular ejection fraction patients with CHF. The goal of this project is to evaluate whether beta(1)-AAbs and M(2)-AAbs predict prognosis and sudden cardiac death (SCD) in CHF. METHODS AND RESULTS: A total of 2062 patients with CHF and 824 control subjects were recruited. Beta(1)-AAbs and M(2)-AAbs were detected by the enzyme-linked immunosorbent assay (ELISA) method, and the correlation between these autoantibodies and the prognosis of CHF was analysed. During a median follow-up period of 36 months (0.40 ± 65 months), 379 (21.56%) cases died-164 had dilated cardiomyopathy (DCM) and 215 had ischaemic cardiomyopathy (ICM). Of these, SCD occurred in 69 cases (40.37%) of DCM and in 84 cases (39.07%) of ICM. Positivity for beta(1)-AAbs in DCM and ICM was significantly higher than for the controls (8.1% and 8.25% v.s 2.2%, both P < 0.01). However, positive M(2)-AAbs did not show any statistical difference between the three groups. Cox regression analysis revealed that positive beta(1)-AAbs were associated with higher mortality in CHF and that it predicted SCD for DCM [hazard ratio (HR) 4.51, 95% confidence interval (CI) 2.405-8.471] and ICM (HR 3.749, 95% CI 2.389-5.884) patients, but not non-SCD (NSCD) patients. CONCLUSIONS: The rates of positive beta(1)-AAbs were higher in CHF patients than in the controls. Positive beta(1)-AAbs might serve as an independent predictor for SCD in patients with CHF.
Authors:
Juanhui Pei; Ning Li; Jingzhou Chen; Xian Li; Yinhui Zhang; Zengwu Wang; Ping Zhang; Kejiang Cao; Jielin Pu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  European journal of heart failure     Volume:  -     ISSN:  1879-0844     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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