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The predictive value of skin prick testing for challenge-proven food allergy: A systematic review.
MedLine Citation:
PMID:  22136629     Owner:  NLM     Status:  Publisher    
To cite this article: Peters RL, Gurrin LC, Allen KJ. The predictive value of skin prick testing for challenge-proven food allergy: A systematic review. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399-3038.2011.01237.x ABSTRACT: Immunoglobulin E-mediated (IgE) food allergy affects 6-8% of children, and the prevalence is believed to be increasing. The gold standard of food allergy diagnosis is oral food challenges (OFCs); however, they are resource-consuming and potentially dangerous. Skin prick tests (SPTs) are able to detect the presence of allergen-specific IgE antibodies (sensitization), but they have low specificity for clinically significant food allergy. To reduce the need for OFCs, it has been suggested that children forgo an OFC if their SPT wheal size exceeds a cutoff that has a high predictability for food allergy. Although data for these studies are almost always gathered from high-risk populations, the 95% positive predictive values (PPVs) vary substantially between studies. SPT thresholds with a high probability of food allergy generated from these studies may not be generalizable to other populations, because of highly selective samples and variability in participant's age, test allergens, and food challenge protocol. Standardization of SPT devices and allergens, OFC protocols including standardized cessation criteria, and population-based samples would all help to improve generalizability of PPVs of SPTs.
Rachel L Peters; Lyle C Gurrin; Katrina J Allen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-4
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  -     ISSN:  1399-3038     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Vic., Australia Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Vic., Australia Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Vic., Australia Department of Paediatrics, The University of Melbourne, Melbourne, Vic., Australia.
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