Document Detail

The predictive value of mean platelet volume in differential diagnosis of non-functional pancreatic neuroendocrine tumors from pancreatic adenocarcinomas.
MedLine Citation:
PMID:  22075321     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the present study is to evaluate in a retrospective manner the diagnostic value of mean platelet volume (MPV) in pancreatic adenocarcinomas and pancreatic neuroendocrine tumors (PNETs).
PATIENTS AND METHODS: A total of 92 patients, who were admitted for pancreatic adenocarcinoma (n=76) and PNET (n=16) between March 2007 and December 2009, were analyzed retrospectively for demographics and clinical information.
RESULTS: Thirty-nine patients (51.3%) had a resectable, whereas 37 patients (48.7%) had an unresectable pancreatic adenocarcinoma. Nine patients (56.3%) had a non-functional PNET, 6 patients (37.5%) had an insulinoma, and the remaining one patient had a gastrinoma. The mean age was 59.3±10.5 for pancreatic adenocarcinomas and 45.1±10.6 for PNETs. The mean age at diagnosis was significantly higher in patients with pancreatic adenocarcinomas than the patients with PNET (p<0.001). Preoperative mean hemoglobin levels were significantly lower in patients with pancreatic adenocarcinoma than those with PNET (12.4±1.8g/dl vs 13.7±2.2g/dl), (p<0.013). The preoperative median MPV levels were significantly lower in patients with PNET 7.8fL (7.2-9.4) than in patients with pancreatic adenocarcinomas 8.6fL (6.6-13.5), (p<0.014). In subgroup analysis, a significant difference in MPV levels was mainly caused by the difference between pancreatic adenocarcinomas and non-functional PNETs (p=0.017). The cut-off value of MPV level for detection of PNETs was calculated as≤7.8fL using ROC analysis [Sensitivity: 66.7%, specificity: 75.9%, AUC: 0.734 (0.587-0.880) p=0.022]. In logistic regression analysis, independent predictive factors for determining PNETs in the differential diagnosis of pancreatic adenocarcinomas were calculated as age (OR=0.068, 95% CI: 0.012-0.398), Ca 19-9 (OR=0.039, 95% CI: 0.006-0.263), MPV (OR=0.595, 95% CI: 0.243-1.458), and hemoglobin (OR=1.317, 95% CI: 0.831-2.086).
CONCLUSION: Age, Ca 19-9, MPV, and hemoglobin levels have diagnostic value for distinguishing PNETs from pancreatic adenocarcinomas.
Kerem Karaman; Erdal Birol Bostanci; Erol Aksoy; Mevlut Kurt; Bahadır Celep; Murat Ulas; Tahsin Dalgic; Ali Surmelioglu; Mutlu Hayran; Musa Akoglu
Publication Detail:
Type:  Journal Article     Date:  2011-06-12
Journal Detail:
Title:  European journal of internal medicine     Volume:  22     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-03-09     Revised Date:  2014-08-01    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e95-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Adenocarcinoma / blood*,  diagnosis*
Biological Markers / metabolism
Blood Platelets / pathology*
CA-19-9 Antigen / blood
Diagnosis, Differential
Hematologic Tests / methods
Hemoglobins / metabolism
Middle Aged
Neuroendocrine Tumors / blood*,  diagnosis*
Pancreatic Neoplasms / blood*,  diagnosis*
Predictive Value of Tests
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/CA-19-9 Antigen; 0/Hemoglobins
Comment In:
Eur J Intern Med. 2014 Jul;25(6):e82   [PMID:  24582330 ]
Eur J Intern Med. 2014 Jul;25(6):e83   [PMID:  24873725 ]

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