Document Detail

The predictive value of creatine phosphokinase and alkaline phosphatase in identification of heterotopic ossification in patients after spinal cord injury.
MedLine Citation:
PMID:  14639555     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the predictive value of serum levels of creatine phosphokinase (CPK) and alkaline phosphatase (ALP) in identifying patients with spinal cord injury (SCI) who are at risk to develop heterotopic ossification (HO) at the hips. DESIGN: Prospective cohort study. SETTING: Tertiary-care level I trauma center. PARTICIPANTS: Consecutive sample of 18 adults with acute traumatic SCI. Patients were excluded if they had medical or surgical conditions that are known to cause elevated enzyme levels. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Conventional hip radiographs were taken approximately 3 weeks after injury and again from between 3 to 6 months after injury. Serum ALP and CPK were measured approximately 3 weeks after SCI. Patients were later separated into 2 groups: group 1 was comprised of those who developed HO and group 2 was comprised of those who did not. RESULTS: The initial radiographs showed no evidence of HO in either group. The radiographs taken at 3 to 6 months showed HO in 7 of 18 patients. The levels of CPK at the initial evaluation were significantly higher (R=.947, P<.0024) in group 1 than in group 2 and correlated with the severity of HO. There was no correlation between serum ALP levels and subsequent development of HO between the 2 groups (P=.07). CONCLUSION: Elevated serum levels of CPK have value in predicting the HO.
Rajendra S Singh; Michael C Craig; Charles R Katholi; Amie B Jackson; James M Mountz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  84     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2003-12-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1584-8     Citation Subset:  AIM; IM    
Department of Radiology, University of Alabama Medical Center, Birmingham, 35233, USA.
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MeSH Terms
Alkaline Phosphatase / blood*
Creatine Kinase / blood*
Injury Severity Score
Middle Aged
Ossification, Heterotopic / etiology*,  radiography
Predictive Value of Tests
Prospective Studies
Spinal Cord Injuries / classification,  complications*,  enzymology
Trauma Centers
Grant Support
Reg. No./Substance:
EC Kinase; EC Phosphatase

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