| The predictive value of creatine phosphokinase and alkaline phosphatase in identification of heterotopic ossification in patients after spinal cord injury. | |
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MedLine Citation:
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PMID: 14639555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the predictive value of serum levels of creatine phosphokinase (CPK) and alkaline phosphatase (ALP) in identifying patients with spinal cord injury (SCI) who are at risk to develop heterotopic ossification (HO) at the hips. DESIGN: Prospective cohort study. SETTING: Tertiary-care level I trauma center. PARTICIPANTS: Consecutive sample of 18 adults with acute traumatic SCI. Patients were excluded if they had medical or surgical conditions that are known to cause elevated enzyme levels. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Conventional hip radiographs were taken approximately 3 weeks after injury and again from between 3 to 6 months after injury. Serum ALP and CPK were measured approximately 3 weeks after SCI. Patients were later separated into 2 groups: group 1 was comprised of those who developed HO and group 2 was comprised of those who did not. RESULTS: The initial radiographs showed no evidence of HO in either group. The radiographs taken at 3 to 6 months showed HO in 7 of 18 patients. The levels of CPK at the initial evaluation were significantly higher (R=.947, P<.0024) in group 1 than in group 2 and correlated with the severity of HO. There was no correlation between serum ALP levels and subsequent development of HO between the 2 groups (P=.07). CONCLUSION: Elevated serum levels of CPK have value in predicting the HO. |
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Authors:
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Rajendra S Singh; Michael C Craig; Charles R Katholi; Amie B Jackson; James M Mountz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 84 ISSN: 0003-9993 ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2003-12-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 1584-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Alabama Medical Center, Birmingham, 35233, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alkaline Phosphatase / blood* Creatine Kinase / blood* Humans Injury Severity Score Middle Aged Ossification, Heterotopic / etiology*, radiography Predictive Value of Tests Prospective Studies Spinal Cord Injuries / classification, complications*, enzymology Trauma Centers |
| Grant Support | |
ID/Acronym/Agency:
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HD 37653/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.3.2/Creatine Kinase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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