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The predictive value of antral follicle count remains unchanged across the menstrual cycle.
MedLine Citation:
PMID:  22014878     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To explore whether the predictive value of antral follicle count (AFC) changes when measured at different times during the menstrual cycle. Antimüllerian hormone (AMH) and AFC are considered to be equally predictive of poor ovarian response; however, AMH is considered to have an advantage over AFC, because AMH concentrations can be measured at any time during the menstrual cycle. DESIGN: Retrospective cohort study. SETTING: Private IVF clinic. PATIENT(S): A total of 3,117 patients with a transvaginal ultrasound within 3 months before their first IVF cycle. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Receiver operating curves (ROCs) were constructed for AFC as a screening test for poor ovarian response (fewer than four eggs collected). The areas under the curve (AUCs) were compared for ROCs from patients at different phases of the cycle. RESULT(S): When all patients except those with polycystic ovaries were included, the AUC was 0.79. Further subgroup ROC analyses revealed that the AUCs did not differ significantly when AFC was measured at different phases of the menstrual cycle. CONCLUSION(S): AFC can be measured regardless of the phase of the menstrual cycle without apparent effect on its predictive value for poor ovarian response.
Luk Rombauts; Joseph L Onwude; Hong W Chew; Beverley J Vollenhoven
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-19
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Women's and Children's Program, Southern Health, Clayton, Melbourne, Victoria, Australia; Monash IVF, Clayton, Melbourne, Victoria, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, Melbourne, Victoria, Australia.
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