| The predictive value of TNF-α and IL-6 and the incidence of macrovascular complications in patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 20495833 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Some inflammation factors have been shown to accelerate type 2 diabetes macrovascular complication (T2DMC). The study investigates the variation of TNF-α and IL-6 levels during the progression of T2DMC to explore their predictive value in the incidence of T2DMC. All participants were divided into two groups, type 2 diabetes mellitus (T2DM) and non-diabetes (ND) group. TNF-α and IL-6 were analyzed with enzyme immunoassay. All participants were followed up by carotid Doppler, Doppler of lower extremities, head CT and 64-row multislice spiral CTA. The incidence of macrovascular atherosclerosis in T2DM was significantly higher than that in ND group (P < 0.05). The levels of TNF-α and IL-6 in both groups with atherosclerosis increased annually. In patients who had atherosclerosis with diabetes, measured levels of TNF-α and IL-6 were significantly higher than those in patients with atherosclerosis without diabetes (P < 0.05). The levels of TNF-α and IL-6 in T2DMC and ND group with atherosclerosis was significantly higher than that in two groups without atherosclerosis (P < 0.05). Patients with T2DM were divided into four groups according to their HbA1C level. There was a strong positive correlation between the levels of TNF-α and IL-6 and HbA1C (P > 0.05). The TNF-α and IL-6 levels can be used as predictors for atherosclerosis development. Compared with non-diabetic atherosclerosis, TNF-α and IL-6 have stronger predictive value in diabetic atherosclerosis development. One reason for hyperglycemia increasing atherosclerosis is to activate inflammatory cells and relives of inflammatory factors. Hyperglycemia can trigger inflammation, which is a quality-effect relationship reaction. |
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Authors:
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Weihua Wu; Mingli Wang; Zhenjie Sun; Xin Wang; Jiajing Miao; Zhaohui Zheng |
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Publication Detail:
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Type: Journal Article Date: 2010-05-21 |
Journal Detail:
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Title: Acta diabetologica Volume: 49 ISSN: 1432-5233 ISO Abbreviation: Acta Diabetol Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: Germany |
Other Details:
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Languages: eng Pagination: 3-7 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, 150001, Harbin, China, hui-90@163.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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