Document Detail


The predictive significance of clinical measures of brain injury in the newborn.
MedLine Citation:
PMID:  8513614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Detailed neurological assessment is of major importance for the accurate diagnosis and prediction of outcome of acute hypoxic-ischemic encephalopathy in the term newborn. Because the clinical features of hypoxic-ischemic encephalopathy are nonspecific, the diagnosis of hypoxic-ischemic cerebral injury should be made with caution and only in the context of historical evidence of intrapartum hypoxic-ischemic insult. In the term newborn, the absence of encephalopathy during the first days of life essentially precludes the occurrence of a significant acute intrapartum hypoxic-ischemic insult as the primary etiology of longterm neurological abnormalities. However, hypoxic-ischemic cerebral injury which originates earlier in gestation may result in few, if any, clinical abnormalities during the newborn period. In premature newborns and term infants on complex life support apparatus, neurological examination during the first days of life is of limited prognostic value. In these instances, greater reliance must be placed on other investigations, e.g. neuroimaging, neurophysiological techniques, and biochemical derangements.
Authors:
A Hill
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  16     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-22     Completed Date:  1993-07-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  141-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of British Columbia, Vancouver.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Injuries / diagnosis*,  etiology
Brain Ischemia / diagnosis*,  etiology
Female
Humans
Hypoxia, Brain / diagnosis*,  etiology
Infant
Infant, Newborn
Infant, Premature
Predictive Value of Tests
Pregnancy
Prognosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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