Document Detail


A predictive model of fatigue in human skeletal muscles.
MedLine Citation:
PMID:  11007565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatigue is a major limitation to the clinical application of functional electrical stimulation. The activation pattern used during electrical stimulation affects force and fatigue. Identifying the activation pattern that produces the greatest force and least fatigue for each patient is, therefore, of great importance. Mathematical models that predict muscle forces and fatigue produced by a wide range of stimulation patterns would facilitate the search for optimal patterns. Previously, we developed a mathematical isometric force model that successfully identified the stimulation patterns that produced the greatest forces from healthy subjects under nonfatigue and fatigue conditions. The present study introduces a four-parameter fatigue model, coupled with the force model that predicts the fatigue induced by different stimulation patterns on different days during isometric contractions. This fatigue model accounted for 90% of the variability in forces produced by different fatigue tests. The predicted forces at the end of fatigue testing differed from those observed by only 9%. This model demonstrates the potential for predicting muscle fatigue in response to a wide range of stimulation patterns.
Authors:
J Ding; A S Wexler; S A Binder-Macleod
Related Documents :
15862865 - Muscle contraction: a new interpretation of the transient behaviour of muscle.
11592325 - Sensitivity analysis and application to trotting of a noninvasive method to calculate f...
9147975 - Determination of spinal facet joint loads from extra articular strains--a theoretical v...
21403915 - Limo eeg: a toolbox for hierarchical linear modeling of electroencephalographic data.
16441375 - Fast identification of ten clinically important micro-organisms using an electronic nose.
18084075 - Experimental determination of optimal root-mean-square deviations of macromolecular bon...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  89     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-25     Completed Date:  2000-11-09     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1322-32     Citation Subset:  IM    
Affiliation:
Interdisciplinary Graduate Program in Biomechanics and Movement Science, University of Delaware, Newark, Delaware 19716, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Electric Stimulation
Humans
Isometric Contraction / physiology*
Leg
Models, Biological*
Muscle Fatigue / physiology*
Muscle, Skeletal / physiology*
Grant Support
ID/Acronym/Agency:
HD-36797/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Venoarterial CO(2) difference during regional ischemic or hypoxic hypoxia.
Next Document:  Neurocirculatory consequences of intermittent asphyxia in humans.