Document Detail


A prediction model for selecting patients undergoing in vitro fertilization for elective single embryo transfer.
MedLine Citation:
PMID:  11937124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Construction of a prediction model to enable the selection of patients for elective single ET. DESIGN: Retrospective cohort study. SETTING: Fertility center in a tertiary referral university hospital. PATIENT(S): Six hundred forty-two women undergoing their first IVF treatment cycle in which no more than two embryos were transferred. INTERVENTION(S): Database analysis. MAIN OUTCOME MEASURE(S): Ongoing pregnancy and multiple pregnancy. RESULT(S): In multivariate analysis, the best predictors for ongoing pregnancy were female age, the number of retrieved oocytes, the developmental stage score and the morphology score of the two best embryos available for transfer, and the day of transfer. Younger age and high quality of transferred embryos were the best predictors for increased risk of multiple pregnancy. The resulting model enables the calculation of probabilities of pregnancy and twin pregnancy. Depending on embryo quality, there is a threshold age under which the chance of singleton pregnancy is higher if one embryo is transferred compared with two embryos. CONCLUSION(S): Application of this model may enable a reduction in the chance of twin pregnancy without compromising singleton pregnancy rates in a subgroup of patients undergoing IVF.
Authors:
Claudine C Hunault; Marinus J C Eijkemans; Math H E C Pieters; Egbert R te Velde; J Dik F Habbema; Bart C J M Fauser; Nicholas S Macklon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  77     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-08     Completed Date:  2003-01-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  725-32     Citation Subset:  IM    
Affiliation:
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus University Medical Center, The, Rotterdam, Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging
Analysis of Variance
Cell Count
Cohort Studies
Embryo Transfer*
Embryo, Mammalian / physiology
Female
Fertilization in Vitro*
Humans
Logistic Models
Odds Ratio
Oocytes
Ovarian Follicle / anatomy & histology
Patient Selection*
Pregnancy
Pregnancy, Multiple
ROC Curve
Retrospective Studies
Sperm Count
Twins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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