Document Detail


A predicted secondary structure of protein protease inhibitors.
MedLine Citation:
PMID:  7342589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Basing on the Chou & Fasman method (Biochemistry, 13, 222-245; 1974) and the known amino acid sequences, the alpha-helical, beta-sheet, beta-turn and random-coil regions were predicted for protein protease inhibitors. It appears that in all the inhibitors examined there is a region conserved in the vicinity of the active site, composed of one beta-turn with an adjacent beta-sheet structure, and a second beta-turn situated in the other part of the polypeptide chain and linked with the first one by disulphide bridge. Two disulphide bridges between Cys2 and Cys25, and between Cys10 and Cys21 were proposed for the squash seed inhibitor. It is suggested that the two beta-turns play an essential role in the process of trypsin inhibition by protein protease inhibitors.
Authors:
P Tłomak; K Nowak
Related Documents :
20506279 - The structure of the fyr domain of transforming growth factor beta regulator 1.
23585919 - Sirtuin deacetylation mechanism and catalytic role of the dynamic cofactor binding loop.
11334619 - Amino acid distributions in integral membrane protein structures.
9466929 - Shear numbers of protein beta-barrels: definition refinements and statistics.
2322539 - Sequential resonance assignment and secondary structure determination of the ascaris tr...
25051489 - A role for na+,k+-atpase α1 in regulating rab27a localisation on melanosomes.
22544739 - Crystal structure of dnak protein complexed with nucleotide exchange factor grpe in dna...
19290549 - Reducing gastric secretions--a role for histamine 2 antagonists or proton pump inhibito...
7738009 - Recognition of the structure around the site of cleavage by the carboxyl-terminal proce...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  28     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1981  
Date Detail:
Created Date:  1982-07-19     Completed Date:  1982-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  241-51     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Protease Inhibitors*
Protein Conformation*
Trypsin Inhibitor, Kunitz Soybean
Chemical
Reg. No./Substance:
0/Protease Inhibitors; 9088-41-9/Trypsin Inhibitor, Kunitz Soybean

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The structure/activity relationship in glyceraldehyde-3-phosphate dehydrogenase of pig muscle.
Next Document:  Homology of the predicted secondary structures of the N-terminal fragments of preproteins.