Document Detail

The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy.
MedLine Citation:
PMID:  20189169     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate associations between preconception dietary patterns and IVF/intracytoplasmic sperm injection (ICSI) outcomes validated by biomarkers of the homocysteine pathway.
DESIGN: Observational prospective study.
SETTING: A tertiary referral fertility clinic at the Erasmus University Medical Centre, Rotterdam, The Netherlands.
PATIENT(S): One hundred sixty-one couples undergoing IVF/ICSI treatment.
INTERVENTION(S): No interventions other than the Dutch governmental recommendation of folic acid.
MAIN OUTCOME MEASURE(S): Dietary patterns, blood and follicular fluid concentrations of folate, vitamin B12, vitamin B6, homocysteine, and fertilization rate, embryo quality, and pregnancy.
RESULT(S): In women, two dietary patterns were identified. The "health conscious-low processed" dietary pattern (variation explained 12.1%) was characterized by high intakes of fruits, vegetables, fish, and whole grains and low intakes of snacks, meats, and mayonnaise, and positively correlated with red blood cell folate (β=0.07). The "Mediterranean" dietary pattern (variation explained 9.1%), that is, high intakes of vegetable oils, vegetables, fish, and legumes and low intakes of snacks, was positively correlated with red blood cell folate (β=0.13), and vitamin B6 in blood (β=0.09) and follicular fluid (β=0.18). High adherence by the couple to the "Mediterranean" diet increased the probability of pregnancy, odds ratio 1.4 (95% confidence interval 1.0-1.9).
CONCLUSION(S): A preconception "Mediterranean" diet by couples undergoing IVF/ICSI treatment contributes to the success of achieving pregnancy.
Marijana Vujkovic; Jeanne H de Vries; Jan Lindemans; Nick S Macklon; Peter J van der Spek; Eric A P Steegers; Régine P M Steegers-Theunissen
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-03-01
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2096-101     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
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MeSH Terms
Combined Modality Therapy
Diet, Mediterranean*
Family Characteristics
Feeding Behavior / physiology
Fertilization in Vitro / methods*
Infertility / diet therapy*
Patient Compliance
Preconception Care / methods*
Sperm Injections, Intracytoplasmic
Treatment Outcome
Young Adult

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