Document Detail

The precarious antioxidant defenses of the preterm infant.
MedLine Citation:
PMID:  11041438     Owner:  NLM     Status:  MEDLINE    
Oxygen radicals are considered to be major causative factors in many illnesses of preterm infants. This article reviews the antioxidant defenses in immature animals and preterm infants, and attempts to quantitate their vulnerabilities to oxidants. Sources of oxidants, including hyperoxia, iron, parenteral nutrition, nitric oxide, and prooxidants, and their impact on immature antioxidant defenses are discussed. Genetic manipulations of antioxidant enzymes such as knockout and transgenic mice models are reviewed. The various clinical and investigational antioxidant therapies in animals and humans and difficulties in the design of antioxidant therapy studies are explored.
D W Thibeault
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of perinatology     Volume:  17     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-22     Completed Date:  2001-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-81     Citation Subset:  IM    
Department of Pediatrics, Children's Mercy Hospital and The University of Missouri-Kansas City School of Medicine, 64108, USA.
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MeSH Terms
Antioxidants* / metabolism
Gene Therapy
Glutathione / analysis
Infant, Newborn
Infant, Premature / physiology*
Infant, Premature, Diseases / physiopathology*
Oxidative Stress / physiology*
Parenteral Nutrition
Vitamin A / metabolism,  therapeutic use
Vitamin E / metabolism,  therapeutic use
Reg. No./Substance:
0/Antioxidants; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 70-18-8/Glutathione

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