| The precarious antioxidant defenses of the preterm infant. | |
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MedLine Citation:
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PMID: 11041438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxygen radicals are considered to be major causative factors in many illnesses of preterm infants. This article reviews the antioxidant defenses in immature animals and preterm infants, and attempts to quantitate their vulnerabilities to oxidants. Sources of oxidants, including hyperoxia, iron, parenteral nutrition, nitric oxide, and prooxidants, and their impact on immature antioxidant defenses are discussed. Genetic manipulations of antioxidant enzymes such as knockout and transgenic mice models are reviewed. The various clinical and investigational antioxidant therapies in animals and humans and difficulties in the design of antioxidant therapy studies are explored. |
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Authors:
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D W Thibeault |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of perinatology Volume: 17 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 2000 |
Date Detail:
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Created Date: 2001-01-22 Completed Date: 2001-02-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 167-81 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Children's Mercy Hospital and The University of Missouri-Kansas City School of Medicine, 64108, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants* / metabolism Gene Therapy Glutathione / analysis Humans Infant, Newborn Infant, Premature / physiology* Infant, Premature, Diseases / physiopathology* Oxidative Stress / physiology* Parenteral Nutrition Vitamin A / metabolism, therapeutic use Vitamin E / metabolism, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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