Document Detail

The pre-Bötzinger complex participates in generating the respiratory effects of thyroliberin.
MedLine Citation:
PMID:  10493545     Owner:  NLM     Status:  MEDLINE    
Experiments on anesthetized rats were performed to study the effects of microinjection of thyroliberin (10 fM-100 microM) into the area of the pre-Bötzinger complex on respiratory and circulatory parameters. Thyroliberin dose-dependently increased respiration frequency, with shortening of inspiration and expiration. Tidal volume and the amplitude of the integrated EMG recorded from the inspiratory muscles decreased after administration of concentrated solutions. Using this dosage method, thyroliberin had weak effects on systemic hemodynamics. The data suggest that structures located in the area of the pre-Bötzinger complex take part in generating the respiratory effects of thyroliberin.
A N Inyushkin; N A Merkulova; S A Chepurnov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience and behavioral physiology     Volume:  29     ISSN:  0097-0549     ISO Abbreviation:  Neurosci. Behav. Physiol.     Publication Date:    1999 May-Jun
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0330471     Medline TA:  Neurosci Behav Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Department of Human and Animal Physiology, The State University, Samara, Russia.
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MeSH Terms
Body Temperature / drug effects
Hemodynamics / drug effects,  physiology
Respiration / drug effects*
Respiratory Center / drug effects,  physiology*
Respiratory Mechanics / drug effects,  physiology
Respiratory Muscles / drug effects,  physiology
Thyrotropin-Releasing Hormone / administration & dosage,  pharmacology*
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone

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