Document Detail


A practical guide to the management of oesophageal varices.
MedLine Citation:
PMID:  10193686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bleeding oesophageal varices are a frequent and sometimes fatal complication of portal hypertension. Prompt resuscitation and arrest of haemorrhage are the immediate short term priorities. Vasoactive therapy to reduce portal pressure is administered on presentation. Early endoscopy is necessary to make a definitive diagnosis and initiate appropriate therapy; usually emergency sclerotherapy or banding. After the acute bleeding episode, follow-up therapy is instituted either to obliterate the varices by sclerotherapy or banding, or to chronically lower portal pressure and hence reduce the risk of bleeding pharmacologically; a combination of both strategies may be also used. Active surveillance of those at risk of developing varices is advocated. Long term beta-blocker therapy has been demonstrated to be effective in both the primary prevention of variceal haemorrhage and the prevention of rebleeding in those who have already bled. Despite a multitude of therapeutic regimes and ongoing clinical trials, mortality from this condition remains disappointingly high.
Authors:
G McCormack; P A McCormick
Related Documents :
3773326 - Reflex renal vasoconstriction on portal vein distension.
16927066 - Effect of portocaval shunt on residual extreme small liver after extended hepatectomy i...
2113096 - Effects of variation in systemic blood pressure on intraosseous pressure, po2, and pco2.
11851646 - The effects of rifampicin on the pharmacokinetics and pharmacodynamics of orally admini...
9090776 - The heart and development.
22955146 - Tibiofemoral contact mechanics following posterior root of medial meniscus tear, repair...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  57     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-02     Completed Date:  1999-06-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  327-35     Citation Subset:  IM    
Affiliation:
The National Liver Unit, St Vincent's Hospital, Dublin, Ireland. germcc@svherc.ucd.ie
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Esophageal and Gastric Varices / drug therapy,  prevention & control,  surgery,  therapy*
Esophagoscopy
Gastrointestinal Hemorrhage / drug therapy,  prevention & control,  surgery,  therapy*
Humans
Portasystemic Shunt, Surgical*
Resuscitation
Salvage Therapy
Sclerotherapy* / adverse effects
Vasoconstrictor Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prospects for the therapeutic use of anticancer vaccines.
Next Document:  Managing resistance to anti-HIV drugs: an important consideration for effective disease management.