Document Detail

A practical dexamethasone suppression test to evaluate hirsute women.
MedLine Citation:
PMID:  6126405     Owner:  NLM     Status:  MEDLINE    
Fifty five hirsute women were subjected to a 2-week dexamethasone (DXM) suppression test. The pre-and post-DXM plasma dehydro-epiandrosterone-sulfate (DS) and testosterone (T) were measured by radioimmunoassay to define the source of androgen excess in hirsute women. Four patients (7%) failed to have adequate adrenal suppression due to failure in medication. Among the 51 patients with adequate adrenal suppression, the source of androgen excess was clearly defined in 48 patients (94%). Seventeen patients (33%) showed ovarian source, 13 patients (26%) had adrenal source, while 18 patients (35%) revealed a mixed adrenal and ovarian source. Normal baselines DS and T levels were noted in 22% of hirsute women and more than half (55%) of them had ovarian androgen excess. Even in 17 patients with normal DS and elevated T, 6 patients (36%) suggested adrenal androgen excess. The source of androgen excess in hirsute women seems evenly distributed among the ovarian, the adrenal, and the mixed group.
C H Wu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  20     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
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MeSH Terms
Adrenal Gland Diseases / diagnosis
Dehydroepiandrosterone / analogs & derivatives*,  blood
Dehydroepiandrosterone Sulfate
Dexamethasone / diagnostic use*
Hirsutism / blood,  diagnosis*
Menstruation Disturbances / etiology
Ovarian Diseases / diagnosis
Testosterone / blood*
Reg. No./Substance:
50-02-2/Dexamethasone; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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