| A practical approach to the prevention of miscarriage: part 5--antiphospholipid syndrome as a cause of spontaneous abortion. | |
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MedLine Citation:
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PMID: 21485715 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To describe the diagnosis and treatment of antiphospholipid syndrome as it relates to spontaneous abortion. METHODS: The relative importance of performing tests of antiphospholipid antibodies that prolong the partial thromboplastin time and other autoantibodies against phospholipids measured by ELISA are discussed. RESULTS: The most important diagnostic tests are the lupus anticoagulant, anticardiolipin antibody and antiphosphatidyl serine. Low molecular weight heparin and low dose aspirin are the two most important therapies. CONCLUSIONS: Women with recurrent miscarriages or even an unexplained miscarriage especially after ten weeks (but sometimes even early first trimester) or a history of thrombosis or intrauterine growth restriction and maybe preeclampsia are candidates for anticoagulant therapy, especially with the presence of significant levels of the lupus anticoagulant or anticardiolipin or antiphosphatidyl serine antibodies (> 40 pl units/ml). |
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Authors:
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J H Check |
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Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: Clinical and experimental obstetrics & gynecology Volume: 38 ISSN: 0390-6663 ISO Abbreviation: Clin Exp Obstet Gynecol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802110 Medline TA: Clin Exp Obstet Gynecol Country: Italy |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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