Document Detail

A practical approach to the prevention of miscarriage: part 2--active immunotherapy.
MedLine Citation:
PMID:  20420268     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To present data suggesting that active immunization with lymphocyte immunotherapy is a treatment that has benefit in preventing miscarriage. METHODS: Lymphocyte immunotherapy is given to women with a history of recurrent miscarriage or failure to achieve a successful pregnancy, despite several previous embryo transfers. Active immunization was combined with progesterone therapy. The lymphocytes were not refrigerated, but used fresh. RESULTS: Compared to controls, i.e., progesterone therapy alone, the injection of paternal lymphocytes intradermally improved miscarriage rates and improved live delivered pregnancy rates per embryo transfer. CONCLUSIONS: The addition of progesterone treatment may act synergistically with lymphocyte immunotherapy, especially in primary aborters and tertiary aborters. However, it is important to use fresh--not refrigerated--stored lymphoctes.
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Publication Detail:
Type:  Editorial    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  37     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
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MeSH Terms
Abortion, Habitual / prevention & control*
Combined Modality Therapy
Embryo Transfer
Enzyme-Linked Immunosorbent Assay
Immunotherapy, Active*
Injections, Intradermal
Live Birth
Lymphocyte Transfusion
Pregnancy Proteins / blood
Pregnancy Rate
Progesterone / therapeutic use
Progestins / therapeutic use
Specimen Handling
Suppressor Factors, Immunologic / blood
Reg. No./Substance:
0/PIBF1 protein, human; 0/Pregnancy Proteins; 0/Progestins; 0/Suppressor Factors, Immunologic; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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