Document Detail

The power of observation.
MedLine Citation:
PMID:  21736661     Owner:  NLM     Status:  In-Data-Review    
Citation Clark DA. The power of observation. Am J Reprod Immunol 2011; 66: 71-75 Problem  In the golden age of evidence-based medicine, how should one view the cohort-controlled study of IVIG + anti-TNF-α (Humira) in recurrent in vitro fertilization (IVF) failure patients with an elevated Th1/Th2 cytokine production ratio. Method  Critical analysis of the nature of evidence for causation. Results A better delivery rate and a live birth rate per embryo approaching the estimated maximum possible in patients whose elevated Th1/Th2 ratio corrected to normal compared to those with an incomplete correction is a strong argument for causation. A maximal improvement when treatment was given 61-120 days before embryo transfer suggests a possible mechanism via improving the physiology during follicle development. Conclusion  Independent replication to verify results would augment power.
David A Clark
Publication Detail:
Type:  Journal Article     Date:  2011-01-18
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  66     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Departments of Medicine, Molecular Medicine & Pathology, & Ob-Gyn., McMaster University, Hamilton, ON, Canada.
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