Document Detail

The potentiation of warfarin anticoagulation by amiodarone.
MedLine Citation:
PMID:  7074739     Owner:  NLM     Status:  MEDLINE    
The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.
A Hamer; T Peter; W J Mandel; M M Scheinman; D Weiss
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  65     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1025-9     Citation Subset:  AIM; IM    
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MeSH Terms
Amiodarone / pharmacology*
Arrhythmias, Cardiac / drug therapy
Benzofurans / pharmacology*
Blood Coagulation / drug effects*
Blood Coagulation Factors / analysis
Drug Synergism
Middle Aged
Prothrombin Time
Vitamin K
Warfarin / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Benzofurans; 0/Blood Coagulation Factors; 12001-79-5/Vitamin K; 1951-25-3/Amiodarone; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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