| The potentiation of the response to blunt cardiac trauma by ethanol in dogs. | |
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MedLine Citation:
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PMID: 3701898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute changes in mechanical performance and electrical activity were followed after blunt cardiac trauma, ethanol infusion, and ethanol infusion and blunt cardiac trauma in 21 anesthetized dogs. Impact was delivered to most of the pericardium with an impact velocity of 10 m/sec and a contact compression of 5 cm. Impact alone caused transient arrhythmias and significant reductions in all hemodynamic parameters with ultimate recovery of rhythm and cardiac performance within 60 minutes after impact. Intravenous infusion of ethanol (average blood alcohol concentration, 65 +/- 1 mg %), resulted in no significant alterations in either mechanical performance or electrical activity but, when combined with trauma, caused a mortality rate of 67%. All animals died from excitation-contraction decoupling; a dissociation of electrical from mechanical activity such that an electrical event does not elicit a mechanical event strong enough to sustain life. It is concluded that even low blood alcohol concentrations can significantly reduce cardiac performance in the presence of otherwise nonfatal cardiac injury. |
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Authors:
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M A Desiderio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 26 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-06-12 Completed Date: 1986-06-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 467-73 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / etiology Blood Pressure / drug effects Dogs Electrocardiography Ethanol / blood, pharmacology* Heart / drug effects Heart Injuries / physiopathology* Heart Rate / drug effects Humans Wounds, Nonpenetrating / physiopathology* |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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