| A potentially antianginal benzo [b]thiophene with an amiodarone-like haemodynamic profile. | |
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MedLine Citation:
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PMID: 238543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L 9146 or 2-methyl-3(3,5 dimethyl-4-gamma-di-n-butylaminopropoxy-benzoyl)-benzo [b] thiophene is a substance belonging to the amiodarone series which induces in the anaesthetized dog a decrease of myocardial oxygen consumption which is mainly due to slowing of the heart rate and reduction in systemic blood pressure. L 9146 also enhances coronary blood flow. L 9146 has also antiadrenergic properties since catecholamine-induced hypertension, tachycardia and increase of myocardial oxygen consumption are markedly antagonized; these antiacrenergic effects are not due to a competitive blockade of the beta-adrenoceptors. L 9146 does not decrease cardiac output, but increases it appreciably in the initial phase of its action. Several findings indicate that when the intensity of certain properties is considered, l9146 is more active than aniodarone since only half the dose used with aniodarone is required to achieve a given level of action. The overall haemodynamic properties of L 9146, which are similar to those of amiodarone, are considered to be potentially valuable for the long-term treatment of angina pectoris. |
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Authors:
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R Charlier; J Bauthier; J Richard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 25 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-09-29 Completed Date: 1975-09-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 46-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology*,
therapeutic use Amiodarone* Angina Pectoris / drug therapy* Animals Benzofurans* Blood Pressure / drug effects Cardiac Output / drug effects Coronary Circulation / drug effects Depression, Chemical Dogs Electrocardiography Epinephrine / antagonists & inhibitors Female Heart Rate / drug effects Hemodynamics / drug effects* Hypertension / chemically induced, drug therapy Isoproterenol / antagonists & inhibitors Male Oxygen Consumption / drug effects Propylamines / pharmacology, therapeutic use Tachycardia / chemically induced, drug therapy Thiophenes / pharmacology*, therapeutic use Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Benzofurans; 0/Propylamines; 0/Thiophenes; 1951-25-3/Amiodarone; 51-43-4/Epinephrine; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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