| The potential use of 2-[¹⁸F]fluoro-2-deoxy-D-galactose as a PET/CT tracer for detection of hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 21553087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of the study was to evaluate the feasibility of using the hepatocyte-specific positron emission tomography (PET) tracer 2-[(18)F]fluoro-2-deoxy-D-galactose (FDGal) as a tracer for hepatocellular carcinoma (HCC). METHODS: In addition to standard clinical investigations, 39 patients with known HCC or suspected of having HCC underwent a partial-body FDGal PET/CT (from base of skull to mid-thigh). Diagnosis of HCC was based on internationally approved criteria. FDGal PET/CT images were analysed for areas with high (hot spots) or low (cold spots) tracer accumulation when compared to surrounding tissue. RESULTS: Seven patients did not have HCC and FDGal PET/CT was negative in each of them. Twenty-three patients had HCC and were included before treatment. FDGal PET/CT correctly identified 22 of these patients, which was comparable to contrast-enhanced CT. Interestingly, FDGal PET/CT was conclusive in 12 patients in whom conventional imaging techniques were inconclusive and required additional diagnostic investigations or close follow-up. Nine patients were included after treatment of HCC and in these patients FDGal PET/CT was able to distinguish between viable tumour tissue as hot spots and areas with low metabolic activity as cold spots. FDGal PET/CT detected extrahepatic disease in nine patients which was a novel finding in eight patients. CONCLUSION: FDGal PET/CT has great clinical potential as a PET tracer for detection of extra- but also intrahepatic HCC. In the present study, the specificity of FDGal PET/CT was 100%, which is very promising but needs to be confirmed in a larger, prospective study. |
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Authors:
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Michael Sørensen; Kim Frisch; Dirk Bender; Susanne Keiding |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-07 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 38 ISSN: 1619-7089 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-08 Completed Date: 2011-11-28 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1723-31 Citation Subset: IM |
Affiliation:
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PET Centre, Aarhus University Hospital, 8000 Aarhus C, Denmark. michael@pet.auh.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biological Transport Carcinoma, Hepatocellular / metabolism, radionuclide imaging* Feasibility Studies Female Fucose / analogs & derivatives*, diagnostic use Humans Liver Neoplasms / metabolism, radionuclide imaging* Male Middle Aged Positron-Emission Tomography and Computed Tomography / methods* Radioactive Tracers Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK074419-01/DK/NIDDK NIH HHS; R01 DK074419-05/DK/NIDDK NIH HHS; R01-DK074419/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radioactive Tracers; 3713-31-3/Fucose; 51146-53-3/2-deoxy-2-fluorogalactose |
| Comments/Corrections | |
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