Document Detail


The potential use of 2-[¹⁸F]fluoro-2-deoxy-D-galactose as a PET/CT tracer for detection of hepatocellular carcinoma.
MedLine Citation:
PMID:  21553087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of the study was to evaluate the feasibility of using the hepatocyte-specific positron emission tomography (PET) tracer 2-[(18)F]fluoro-2-deoxy-D-galactose (FDGal) as a tracer for hepatocellular carcinoma (HCC).
METHODS: In addition to standard clinical investigations, 39 patients with known HCC or suspected of having HCC underwent a partial-body FDGal PET/CT (from base of skull to mid-thigh). Diagnosis of HCC was based on internationally approved criteria. FDGal PET/CT images were analysed for areas with high (hot spots) or low (cold spots) tracer accumulation when compared to surrounding tissue.
RESULTS: Seven patients did not have HCC and FDGal PET/CT was negative in each of them. Twenty-three patients had HCC and were included before treatment. FDGal PET/CT correctly identified 22 of these patients, which was comparable to contrast-enhanced CT. Interestingly, FDGal PET/CT was conclusive in 12 patients in whom conventional imaging techniques were inconclusive and required additional diagnostic investigations or close follow-up. Nine patients were included after treatment of HCC and in these patients FDGal PET/CT was able to distinguish between viable tumour tissue as hot spots and areas with low metabolic activity as cold spots. FDGal PET/CT detected extrahepatic disease in nine patients which was a novel finding in eight patients.
CONCLUSION: FDGal PET/CT has great clinical potential as a PET tracer for detection of extra- but also intrahepatic HCC. In the present study, the specificity of FDGal PET/CT was 100%, which is very promising but needs to be confirmed in a larger, prospective study.
Authors:
Michael Sørensen; Kim Frisch; Dirk Bender; Susanne Keiding
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-07
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  38     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-08     Completed Date:  2011-11-28     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1723-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Transport
Carcinoma, Hepatocellular / metabolism,  radionuclide imaging*
Feasibility Studies
Female
Fucose / analogs & derivatives*,  diagnostic use
Humans
Liver Neoplasms / metabolism,  radionuclide imaging*
Male
Middle Aged
Multimodal Imaging / methods*
Positron-Emission Tomography*
Radioactive Tracers
Retrospective Studies
Tomography, X-Ray Computed*
Grant Support
ID/Acronym/Agency:
R01 DK074419/DK/NIDDK NIH HHS; R01 DK074419-01/DK/NIDDK NIH HHS; R01 DK074419-05/DK/NIDDK NIH HHS; R01-DK074419/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Radioactive Tracers; 3713-31-3/Fucose; 51146-53-3/2-deoxy-2-fluorogalactose
Comments/Corrections

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